Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction.

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Research Abstract Details 

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Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Abstract Text:

Xuesen Li,Zhongbo Liu,Cheng Luo,Haiqun Jia,Lijuan Sun,Bei Hou,Weili Shen,Lester Packer,Carl W Cotman,Jiankang Liu,

alpha-Lipoic acid (LA) has been widely studied as an agent for preventing and treating various diseases associated with oxidative disruption of mitochondrial functions. To investigate a related mitochondrial antioxidant, we compared the effects of lipoamide (LM), the neutral amide of LA, with LA for measures of oxidative damage and mitochondrial dysfunction in a human retinal pigment epithelial (RPE) cell line. Acrolein, a major component of cigarette smoke and a product of lipid peroxidation, was used to induce oxidative mitochondrial damage in RPE cells. Overall, using comparable concentrations, LM was more effective than LA at preventing acrolein-induced mitochondrial dysfunction and oxidative stress. Relative to LA, LM improved ATP levels, membrane potentials, and activities of mitochondrial complexes I, II, and V and dehydrogenases that had been decreased by acrolein exposure. LM reduced acrolein-induced oxidant generation, calcium levels, protein oxidation, and DNA damage to a greater degree than LA. And, total antioxidant capacity, glutathione content, glutathione S-transferase, and superoxide dismutase activities and expression of nuclear factor-E2-related factor 2 were increased by LM relative to LA. These results suggest that LM is a more potent mitochondrial-protective agent and antioxidant than LA in protecting RPE from oxidative damage.

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Publishing Authors By Initials

X Li,Z Liu,C Luo,H Jia,L Sun,B Hou,W Shen,L Packer,CW Cotman,J Liu,

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Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Free radical biology & medicine

VOLUME: 44

Page Numbers: 1465-74

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ISSN: 0891-5849

DAY: 18

MONTH: 01

YEAR: 2008

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Information

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LANGUAGE: eng

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Country: United States

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MEDLINETA: Free Radic Biol Med

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