Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic.

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. Research Abstract Details 

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Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. Abstract Text:

Bartz,Wen-Hong Li,Barney Venables,John K Zehmer,Mary R Roth,Ruth Welti,Richard G W Anderson,Pingsheng Liu,Kent D Chapman,

Lipid droplets are accumulations of neutral lipids surrounded by a monolayer of phospholipids and associated proteins. Recent proteomic analysis of isolated droplets suggests that they are part of a dynamic organelle system that is involved in membrane traffic as well as packaging and distributing lipids in the cell. To gain a better insight into the function of droplets, we used a combination of mass spectrometry and NMR spectroscopy to characterize the lipid composition of this compartment. In addition to cholesteryl esters and triacylglycerols with mixed fatty acid composition, we found that approximately 10-20% of the neutral lipids were the ether lipid monoalk(en)yl diacylglycerol. Although lipid droplets contain only 1-2% phospholipids by weight, >160 molecular species were identified and quantified. Phosphatidylcholine (PC) was the most abundant class, followed by phosphatidylethanolamine (PE), phosphatidylinositol, and ether-linked phosphatidylcholine (ePC). Relative to total membrane, droplet phospholipids were enriched in lysoPE, lysoPC, and PC but deficient in sphingomyelin, phosphatidylserine, and phosphatidic acid. These results suggest that droplets play a central role in ether lipid metabolism and intracellular lipid traffic.

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. Publishing Authors By Initials

R Bartz,WH Li,B Venables,JK Zehmer,MR Roth,R Welti,RG Anderson,P Liu,KD Chapman,

For similar lipids: glycerides: triglycerides research abstracts see: lipids: glycerides: triglycerides research

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Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of lipid research

VOLUME: 48

Page Numbers: 837-47

Journal Abbreviation: J. Lipid Res.

ISSN: 0022-2275

DAY: 8

MONTH: 01

YEAR: 2007

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. Information

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LANGUAGE: eng

NlmUniqueID: 376606

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. Keywords Mesh Terms:

KEYWORDS: Triglycerides

MESH TERMS: analysis

Chemical & Substance for Abstract: Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic. Information

Substance Name: Triglycerides

Registry Number: 0

Grant and Affiliation Information for Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic.

AFFILIATION: Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA.

Country: United States

AGENCY: United States NCRR

GRANT: P20 RR-016475

ACRONYM: RR

MEDLINETA: J Lipid Res

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