Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease.

Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease. Research Abstract Details 

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Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease. Abstract Text:

D Dinci?,P Jovi?,S Obradovi?,P Popovi?,M Prcovi?,

Atherosclerotic changes on the coronary arteries are the basis of the ischemic heart disease. It is assumed that the initial changes in this process occur as a consequence of the lipid peroxidation in the vessel wall. We estimated this process through the level of malondialdehyde (MDA) in the serum of 86 patients in whom selective coronary angiography was done for the suspected ischemic heart disease. According to the number of the stenotic coronary arteries (stenosis greater than 50%), we divided the patients into four groups: the control group with normal coronary angiography finding, simple, double or triple vessel coronary disease. In all the patients we also estimated the other parameters of the lipid status (cholesterol, triglycerides, LDL, HDL, Apo-AI, Apo B) and atherogenic indices Apo-AI/Apo B, LDL/HDL and HDL/total cholesterol. No significant changes were observed in the lipid parameters between the control and experimental group. However, mean MDA level in the whole experimental group was 3.89 mumol/L, 3.93 mumol/L in triple vessel coronary disease, 3.83 mumol/L in double vessel and 3.92 mumol/L in single vessel disease group. The difference between all the experimental and the control group was highly significant (p < 0.001). We concluded that the level of MDA--lipid peroxidation index had the better correlation with the disease status than the other parameters of lipid status and the sensitive atherogenic indices.

Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease. Publishing Authors By Initials

D Dinci?,P Jovi?,S Obradovi?,P Popovi?,M Prcovi?,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

PUBMED ID PMID:

MEDLINE DATE: 1998 Jul-Aug

Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vojnosanitetski pregled. Military-medical and phar

VOLUME: 55

Page Numbers: 359-67

Journal Abbreviation:

ISSN: 0042-8450

DAY: 9

MONTH: 01

YEAR: 2008

Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 21530700

Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: blood

Chemical & Substance for Abstract: Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease. Information

Substance Name: Malondialdehyde

Registry Number: 542-78-9

Grant and Affiliation Information for Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease.

AFFILIATION: Clinic for Cardiology, Belgrade.

Country: YUGOSLAVIA

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Vojnosanit Pregl

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