Lipid mediators as agonists for the resolution of acute lung inflammation and injury.

Lipid mediators as agonists for the resolution of acute lung inflammation and injury. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Lipid mediators as agonists for the resolution of acute lung inflammation and injury. Abstract Text:

Caroline Bonnans,Bruce D Levy,

Resolution of acute lung inflammation and injury is an active process; it is not merely the absence of proinflammatory signals. Restoration of homeostasis is coordinated by specific mediators and cellular events. In response to injury and inflammatory stimuli, infiltrating leukocytes and tissue-resident cells interact to generate lipoxins (LXs), which are bioactive eicosanoids derived from arachidonic acid. In contrast to proinflammatory leukotrienes and prostaglandins, LXs display potent antiinflammatory actions. LXA(4) interacts with a G protein-coupled receptor, termed ALX, that transduces counter-regulatory signals in part via intracellular polyisoprenyl phosphate remodeling. Presqualene diphosphate (PSDP) is a polyisoprenyl phosphate in human neutrophils that is rapidly converted to presqualene monophosphate (PSMP) upon cell activation. PSDP, but not PSMP, directly inhibits phospholipase D, phosphoinositol-3 kinase, and superoxide anion generation. LXs block PSDP turnover in neutrophil membranes to prevent proinflammatory responses. Hence, LX and polyisoprenyl phosphate signaling provide a counter-regulatory circuit to promote resolution of acute lung inflammation. LXA(4) and PSDP mimetics have been prepared with potent protective actions in murine models of asthma and acute lung injury.

Lipid mediators as agonists for the resolution of acute lung inflammation and injury. Publishing Authors By Initials

C Bonnans,BD Levy,

For similar respiratory tract diseases: lung diseases: respiratory distress syndrome, adult research abstracts see: respiratory tract diseases: lung diseases: respiratory distress syndrome, adult research

PUBMED ID PMID:

MEDLINE DATE:

Lipid mediators as agonists for the resolution of acute lung inflammation and injury. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of respiratory cell and molecular

VOLUME: 36

Page Numbers: 201-5

Journal Abbreviation: Am. J. Respir. Cell Mol. Biol.

ISSN: 1044-1549

DAY: 21

MONTH: 09

YEAR: 2006

Lipid mediators as agonists for the resolution of acute lung inflammation and injury. Information

Number of References: 48

LANGUAGE: eng

NlmUniqueID: 8917225

Lipid mediators as agonists for the resolution of acute lung inflammation and injury. Keywords Mesh Terms:

KEYWORDS: Respiratory Distress Syndrome, Adult

MESH TERMS: therapy

Chemical & Substance for Abstract: Lipid mediators as agonists for the resolution of acute lung inflammation and injury. Information

Substance Name: Receptors, Lipoxin

Registry Number: 0

Grant and Affiliation Information for Lipid mediators as agonists for the resolution of acute lung inflammation and injury.

AFFILIATION: Department of Respiratory Disease, Arnaud de Villeneuve Hospital, Montpellier, France.

Country: United States

AGENCY: United States NHLBI

GRANT: HL68669

ACRONYM: HL

MEDLINETA: Am J Respir Cell Mol Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Lipid mediators as agonists for the resolution of acute lung inflammation and injury Related Publications

• "Sweet" hydrothorax complicating chronic peritoneal dialysis.
• A model system for mapping vascular responses to complex hemodynamics at arterial bifurcations in vivo.
• Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells.
• Comparison of the intakes of sugars by young children with and without dental caries experience.
• Computerised tomography in Alzheimer's disease. Methods of scan analysis, comparison with normal controls, and clinical/radiological associations.
• Conformational dynamics of substrate in the active site of cytochrome P450 BM-3/NPG complex: insights from NMR order parameters.
• Conformational equilibrium of cytochrome P450 BM-3 complexed with N-palmitoylglycine: a replica exchange molecular dynamics study.
• Cosmetic laser journal watch.
• Epac- and Rap- independent ERK1/2 phosphorylation induced by Gs-coupled receptor stimulation in HEK293 cells.
• Haptoglobin genotype determines myocardial infarct size in diabetic mice.
• Humoral immune response and immunoglobulin G Fc receptor genotype are associated with better clinical outcome following idiotype vaccination in follicular lymphoma patients regardless of their response to induction chemotherapy.
• Imerslund-Grasbeck syndrome associated with recurrent aphthous stomatitis and defective neutrophil function.
• Immobilization of gene vector on polyurethane surface using monoclonal antibody for site-specific gene therapy.
• Increasing the power for detecting impairment in older adults with the Faces subtest from Wechsler Memory Scale-III: an empirical trial.
• Lipid mediators as agonists for the resolution of acute lung inflammation and injury.
• MarA-like regulator of multidrug resistance in Yersinia pestis.
• Molecular characterization of trichomonads from feces of dogs with diarrhea.
• Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.
• Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR.
• Pancreatic encephalopathy-a rare complication of a common disease.
• Recent trends in adolescent substance use, primary care screening, and updates in treatment options.
• Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells.
• Survival and function of MiHA epitope-specific host CD8 TM cells following ablative conditioning and HCT.
• Temperature weighted histogram analysis method, replica exchange, and transition paths.
• The clinical aspects of newborn screening: importance of newborn screening follow-up.
• The replacement of human insulin with insulin analogs: a survey conducted in france to determine current and recommended practice.
• Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events.
• What's in this issue.
• What's in this issue.
• What's in this issue?