Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester.

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Abstract Text:

Joanna Bacon,Lynn G Dover,Kim A Hatch,Yi Zhang,Jessica M Gomes,Sharon Kendall,Lorenz Wernisch,Neil G Stoker,Philip D Butcher,Gurdyal S Besra,Philip D Marsh,

The low level of available iron in vivo is a major obstacle for microbial pathogens and is a stimulus for the expression of virulence genes. In this study, Mycobacterium tuberculosis H37Rv was grown aerobically in the presence of limited iron availability in chemostat culture to determine the physiological response of the organism to iron-limitation. A previously unidentified wax ester accumulated under iron-limited growth, and changes in the abundance of triacylglycerol and menaquinone were also observed between iron-replete and iron-limited chemostat cultures. DNA microarray analysis revealed differential expression of genes involved in glycerolipid metabolism and isoprenoid quinone biosynthesis, providing some insight into the underlying genetic changes that correlate with cell-wall lipid profiles of M. tuberculosis growing in an iron-limited environment.

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Publishing Authors By Initials

J Bacon,LG Dover,KA Hatch,Y Zhang,JM Gomes,S Kendall,L Wernisch,NG Stoker,PD Butcher,GS Besra,PD Marsh,

For similar organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: polycyclic hydrocarbons, aromatic: naphthalenes: naphthoquinones: vitamin k: vitamin k 2 research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: polycyclic hydrocarbons, aromatic: naphthalenes: naphthoquinones: vitamin k: vitamin k 2 research

PUBMED ID PMID:

MEDLINE DATE:

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbiology (Reading, England)

VOLUME: 153

Page Numbers: 1435-44

Journal Abbreviation:

ISSN: 1350-0872

DAY: 28

MONTH: May

YEAR: 2007

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9430468

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Keywords Mesh Terms:

KEYWORDS: Vitamin K 2

MESH TERMS: analysis

Chemical & Substance for Abstract: Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester.

AFFILIATION: TB Research group, Health Protection Agency, Centre for Emergency Preparedness and Response, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. Joanna.bacon@hpa.org.uk

Country: England

AGENCY: United Kingdom Wellcome T

GRANT:

ACRONYM:

MEDLINETA: Microbiology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester Related Publications

• A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.
• A functional approach to transcriptome profiling: linking gene expression patterns to metabolites that matter.
• A novel technique for NOD2/CARD15 genotyping using PCR-SSP.
• Bovine trichomoniasis: Results of a slaughter survey in Colorado and Nebraska.
• Deuterium isotope effects in the unusual addition of toluene to fumarate catalyzed by benzylsuccinate synthase.
• Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women.
• Evaluation of radiometric faecal culture and direct PCR on pooled faeces for detection of Mycobacterium avium subsp. paratuberculosis in cattle.
• Evidence for coupled motion and hydrogen tunneling of the reaction catalyzed by glutamate mutase.
• Identification of NR1I2 genetic variation using resequencing.
• Impact of pharmacogenomics on clinical practice in oncology.
• Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.
• In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53.
• Late death after unrelated-BMT for dyskeratosis congenita following conditioning with alemtuzumab, fludarabine and melphalan.
• Letters to the editor.
• Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester.
• Mechanism of benzylsuccinate synthase probed by substrate and isotope exchange.
• Microbial biofilm formation in DUWS and their control using disinfectants.
• Nomenclature for factors of the HLA system, update July 2007.
• Nomenclature for factors of the HLA system, update June 2007.
• Nucleolar localization of parafibromin is mediated by three nucleolar localization signals.
• Pharmacogenomics.
• Primary cardiac synovial sarcoma: a case report and brief review of the literature.
• Pyrosequencing applications.
• Reconstructing mammalian membrane architecture by large area cellular tomography.
• Taming the tools of violence.
• The IMGT/HLA and IPD databases.
• The effect of hearing loss on identification of asynchronous double vowels.
• The relation of attachment security to adolescents' paternal and peer relationships, depression, and externalizing behavior.
• The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival.
• Time-resolved measurements of the photolysis and recombination of adenosylcobalamin bound to glutamate mutase.