[Lipase/amylase ratio in biliary acute pancreatitis and alcoholic acute/acutized chronic pancreatitis]

[Lipase/amylase ratio in biliary acute pancreatitis and alcoholic acute/acutized chronic pancreatitis] Research Abstract Details 

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[Lipase/amylase ratio in biliary acute pancreatitis and alcoholic acute/acutized chronic pancreatitis] Abstract Text:

Pacheco,Luiz Carlos Marques de Oliveira,Ricardo Custódio Pacheco,Luiz Carlos Marques de Oliveira,

BACKGROUND: Alcoholic or biliary acute pancreatitis may need different therapeutic approaches. AIM: Assessing the validity of lipase/amylase ratio in differentiating biliary from alcoholic acute pancreatitis/acutized chronic pancreatitis. METHODS: Nine male patients (mean age and standard deviation: 39.8 +/- 7.0 years) with alcoholic acute pancreatitis/acutized chronic pancreatitis (group I) and 29 patients, 8 male and 21 female (mean age: 43.6 +/-19.9 years), with biliary acute pancreatitis (group II) were evaluated. Serum lipase and amylase levels were measured in patients with symptoms for no more than 48 hours. The lipase/amylase ratio was calculated based on serum lipase and amylase levels and expressed as multiples of their respective superior reference values. RESULTS: Mean levels of serum lipase (4,814 +/- 3,670 U/L) and amylase (1,282 +/- 777 U/L) in patients of group I were comparable to group II (2,697 +/- 2,391 and 1,878 +/- 1,319 U/L, respectively), but the mean lipase/amylase ratio was significantly higher in group I (4.4 +/- 3.6) than in group II (2.2 +/- 2.2). Lipase/amylase ratio >3 occurred at significantly higher proportions in patients of group I (66.7%) than of group II (24.1%), differentiating the two groups with sensitivity of 67% and specificity of 76%. CONCLUSIONS: 1) Amylase and lipase serum levels did not differ in the two groups evaluated; 2) the lipase/amylase ratio >3 was more often seen in alcoholic acute pancreatitis/acutized chronic pancreatitis than biliary acute pancreatitis, and it may be useful in differentiating these two causes of pancreatitis.

[Lipase/amylase ratio in biliary acute pancreatitis and alcoholic acute/acutized chronic pancreatitis] Publishing Authors By Initials

RC Pacheco,LC Oliveira,RC Pacheco,LC Oliveira,

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[Lipase/amylase ratio in biliary acute pancreatitis and alcoholic acute/acutized chronic pancreatitis] Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Arquivos de gastroenterologia

VOLUME: 44

Page Numbers: 35-8

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ISSN: 0004-2803

DAY: 19

MONTH: 07

YEAR: 2007

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LANGUAGE: por

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AFFILIATION: Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal de Uberlândia, Uberlândia, MG.

Country: Brazil

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MEDLINETA: Arq Gastroenterol

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