Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity.

Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity. Research Abstract Details 

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Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity. Abstract Text:

Jennifer M Spaethling,Donna M Geddes-Klein,William J Miller,Catherine R von Reyn,Pallab Singh,Mahlet Mesfin,Steven J Bernstein,David F Meaney,

Traumatic brain injury (TBI) represents one of most common disorders to the central nervous system (CNS). Despite significant efforts, though, an effective clinical treatment for TBI is not yet available. The complexity of human TBI is modeled with a broad group of experimental models, with each model matching some aspect of the human condition. In the past 15 years, these in vivo models were complemented with a group of in vitro models, with these in vitro models allowing investigators to more precisely identify the mechanism(s) of TBI, the different intracellular events that occur in acute period following injury, and the possible treatment of this injury in vitro. In this paper, we review the available in vitro models to study TBI, discuss their biomechanical basis for human TBI, and review the findings from these in vitro models. Finally, we synthesize the current knowledge and point out possible future directions for this group of models, especially in the effort toward developing new therapies for the traumatically brain injured patient.

Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity. Publishing Authors By Initials

JM Spaethling,DM Geddes-Klein,WJ Miller,CR von Reyn,P Singh,M Mesfin,SJ Bernstein,DF Meaney,

For similar nervous system diseases: trauma, nervous system research abstracts see: nervous system diseases: trauma, nervous system research

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Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in brain research

VOLUME: 161

Page Numbers: 27-39

Journal Abbreviation: Prog. Brain Res.

ISSN: 0079-6123

DAY: 3

MONTH: 12

YEAR: 2007

Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity. Information

Number of References: 119

LANGUAGE: eng

NlmUniqueID: 376441

Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity. Keywords Mesh Terms:

KEYWORDS: Trauma, Nervous System

MESH TERMS: pathology

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Grant and Affiliation Information for Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity.

AFFILIATION: Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104-6392, USA.

Country: Netherlands

AGENCY: United States NICHD

GRANT: R01 HD-41699

ACRONYM: HD

MEDLINETA: Prog Brain Res

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