Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling.

Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling. Research Abstract Details 

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Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling. Abstract Text:

Xiao-Peng Zhang,Zhang Cheng,Feng Liu,Wei Wang,Xiao-Peng Zhang,Zhang Cheng,Feng Liu,Wei Wang,

Interlinked positive feedback loops are frequently found in biological signaling pathways. It is intriguing to study the dynamics, functions, and robustness of these motifs. Using numerical simulations and theoretical analysis, here we explore the sensitiveness and robustness of positive feedback loops with various time scales. Both single and dual loops can behave as a bistable switch. We study the responses of five types of bistable switches to noisy stimuli. The noise-induced transitions between two states are discussed in detail by using energy landscape. The dual-time switch, consisting of interconnected fast and slow loops, is both sensitive to stimuli and resistant to fluctuations in stimulus. This provides a novel mechanism for creating optimal bistable switches and memory modules. Our results also suggest that the dual-time switch can act as a ubiquitous motif with sensitive robustness in biological systems.

Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling. Publishing Authors By Initials

XP Zhang,Z Cheng,F Liu,W Wang,XP Zhang,Z Cheng,F Liu,W Wang,

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Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physical review. E, Statistical, nonlinear, and so

VOLUME: 76

Page Numbers: 031924

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ISSN: 1539-3755

DAY: 27

MONTH: 09

YEAR: 2007

Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling.

AFFILIATION: National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093, China.

Country: United States

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MEDLINETA: Phys Rev E Stat Nonlin Soft Ma

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