Lineage specification in neural crest cell pathfinding.

Lineage specification in neural crest cell pathfinding. Research Abstract Details 

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Lineage specification in neural crest cell pathfinding. Abstract Text:

Melissa L Harris,Carol A Erickson,

There are two principal models to explain neural crest patterning. One assumes that neural crest cells are multipotent precursors that migrate throughout the embryo and differentiate according to cues present in the local environment. A second proposes that the neural crest is a population of cells that becomes restricted to particular fates early in its existence and migrates along particular pathways dependent on unique cell-autonomous properties. Although it is now evident that the neural crest cell population, as a whole, is actually heterogenous (composed of both multipotent and restricted progenitors), evidence supporting the model of prespecification has increased over the past few years. This review will begin by telling the story of melanoblasts: a neural crest subpopulation that is biased toward a single fate and subsequently acquires intrinsic properties that guide cells of this lineage to their final destination. The remainder of this review will explore whether this model is exclusive to melanoblasts or if it can also be used to explain the patterning of other neural crest cells like those of the sensory, sympathoadrenal, and enteric lineages.

Lineage specification in neural crest cell pathfinding. Publishing Authors By Initials

ML Harris,CA Erickson,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

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Lineage specification in neural crest cell pathfinding. Journal Published:

PUBLICATION TYPE: Review

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 1-19

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 3

MONTH: Jan

YEAR: 2007

Lineage specification in neural crest cell pathfinding. Information

Number of References: 191

LANGUAGE: eng

NlmUniqueID: 9201927

Lineage specification in neural crest cell pathfinding. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: metabolism

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Grant and Affiliation Information for Lineage specification in neural crest cell pathfinding.

AFFILIATION: Section of Molecular and Cellular Biology, University of California, Davis, California 95616, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM53258

ACRONYM: GM

MEDLINETA: Dev Dyn

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