Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions.

Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions. Research Abstract Details 

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Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions. Abstract Text:

K Suzuki,S Tsuji,S Kubota,Y Kimura,K Imahori,

Ca2+-activated neutral protease (CANP) usually requires mM Ca2+ for activation. The sensitivity of CANP to Ca2+ is greatly enhanced by passing it through a casein-Sepharose column in the presence of Ca2+ ions. This conversion is ascribed to autolysis of CANP. The converted enzyme required 40 microM Ca2+ for 50% activation. Various properties of the converted enzyme were very similar to those of CANP-I, recently found in canine heart muscle. Names of "m-CANP" and "mu-CANP" are proposed for CANPs which require mM and microM order Ca2+ for inactivation, respectively.

Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions. Publishing Authors By Initials

K Suzuki,S Tsuji,S Kubota,Y Kimura,K Imahori,

For similar carbohydrates: polysaccharides: sepharose research abstracts see: carbohydrates: polysaccharides: sepharose research

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Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 90

Page Numbers: 275-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jul

YEAR: 1981

Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions. Keywords Mesh Terms:

KEYWORDS: Sepharose

MESH TERMS: enzymology

Chemical & Substance for Abstract: Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions. Information

Substance Name: Calpain

Registry Number: EC 3.4.22.-

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Country: JAPAN

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MEDLINETA: J Biochem

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