Lifetime occupation, education, smoking, and risk of ALS.

Lifetime occupation, education, smoking, and risk of ALS. Research Abstract Details 

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Lifetime occupation, education, smoking, and risk of ALS. Abstract Text:

N A Sutedja,J H Veldink,K Fischer,H Kromhout,J H J Wokke,M H B Huisman,D J J Heederik,L H Van den Berg,N A Sutedja,J H Veldink,K Fischer,H Kromhout,J H J Wokke,M H B Huisman,D J J Heederik,L H Van den Berg,

OBJECTIVE: To investigate the association between cigarette smoking, level of education, occupation, and the occurrence of sporadic amyotrophic lateral sclerosis (ALS). METHODS: A total of 364 patients and 392 controls completed a questionnaire covering smoking habits, level of education, and occupational history. Main occupations were coded according to the International Standard Classification of Occupations and compared between patients and controls. RESULTS: The univariate analysis showed an increased risk of developing ALS among current cigarette smokers (OR = 1.7; 95% CI = 1.1 to 2.6; p = 0.01), those with a low level of education (elementary school) (OR = 2.2; 95% CI = 1.2 to 3.8; p < 0.01), and among women whose main occupation was classified as crafts and related trades workers (OR = 8.4; 95% CI = 1.0 to 70.1; p = 0.05). Multivariate analysis (with covariates age, smoking, education, and occupation) showed an increased risk for current smokers of cigarettes (OR = 1.6; 95% CI = 1.0 to 2.5; p = 0.04). CONCLUSIONS: Occupation, education, and cigarette smoking are risk factors for amyotrophic lateral sclerosis, but only smoking appeared independently associated.

Lifetime occupation, education, smoking, and risk of ALS. Publishing Authors By Initials

NA Sutedja,JH Veldink,K Fischer,H Kromhout,JH Wokke,MH Huisman,DJ Heederik,LH Van den Berg,NA Sutedja,JH Veldink,K Fischer,H Kromhout,JH Wokke,MH Huisman,DJ Heederik,LH Van den Berg,

For similar behavior and behavior mechanisms: behavior: habits: smoking research abstracts see: behavior and behavior mechanisms: behavior: habits: smoking research

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Lifetime occupation, education, smoking, and risk of ALS. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurology

VOLUME: 69

Page Numbers: 1508-14

Journal Abbreviation: Neurology

ISSN: 1526-632X

DAY: 9

MONTH: Oct

YEAR: 2007

Lifetime occupation, education, smoking, and risk of ALS. Information

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LANGUAGE: eng

NlmUniqueID: 401060

Lifetime occupation, education, smoking, and risk of ALS. Keywords Mesh Terms:

KEYWORDS: Smoking

MESH TERMS: epidemiology

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Grant and Affiliation Information for Lifetime occupation, education, smoking, and risk of ALS.

AFFILIATION: Department of Neurology, G03.228, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.

Country: United States

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MEDLINETA: Neurology

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