Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies.

Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies. Research Abstract Details 

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Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies. Abstract Text:

Masato Yoneda,Hiroki Endo,Yuichi Nozaki,Ayako Tomimoto,Toshio Fujisawa,Koji Fujita,Kyoko Yoneda,Hirokazu Takahashi,Satoru Saito,Tomoyuki Iwasaki,Shogo Yamamoto,Shuichi Tsutsumi,Hiroyuki Aburatani,Koichiro Wada,Kikuko Hotta,Atsushi Nakajima,Masato Yoneda,Hiroki Endo,Yuichi Nozaki,Ayako Tomimoto,Toshio Fujisawa,Koji Fujita,Kyoko Yoneda,Hirokazu Takahashi,Satoru Saito,Tomoyuki Iwasaki,Shogo Yamamoto,Shuichi Tsutsumi,Hiroyuki Aburatani,Koichiro Wada,Kikuko Hotta,Atsushi Nakajima,

Nonalcoholic steatohepatitis (NASH) is a subset of nonalcoholic fatty liver disease (NAFLD) and sometimes progresses to cirrhosis and liver failure. We analyzed the expression profiles of approximately 50,000 genes and biological pathways in NASH patients in comparison with simple steatosis patients by using the analytical technique of GSEA (Gene Set Enrichment Analysis) by DNA microarrays. Although expressions of various genes were altered, GSEA showed clearly lower expression of nuclear receptors, including the peroxisome proliferator-activated receptor gamma (PPARgamma) pathway. In a preliminary study we therefore investigated the therapeutic effect of low-dose pioglitazone (15 mg/day per body for 24 weeks), a synthetic ligand for PPARgamma, in 12 NASH patients. A decrease in aminotransferase (ALT) values to within the normal range was observed in 7 (58.3%) of the patients, and because the dose of pioglitazone was lower than that ordinarily used, no side effects, such as fatigue, lower extremity edema, or weight gain, were observed. In conclusion, the results confirmed involvement of the PPARgamma pathway in NASH and the therapeutic utility of a PPARgamma ligand.

Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies. Publishing Authors By Initials

M Yoneda,H Endo,Y Nozaki,A Tomimoto,T Fujisawa,K Fujita,K Yoneda,H Takahashi,S Saito,T Iwasaki,S Yamamoto,S Tsutsumi,H Aburatani,K Wada,K Hotta,A Nakajima,M Yoneda,H Endo,Y Nozaki,A Tomimoto,T Fujisawa,K Fujita,K Yoneda,H Takahashi,S Saito,T Iwasaki,S Yamamoto,S Tsutsumi,H Aburatani,K Wada,K Hotta,A Nakajima,

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Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of pharmacological sciences

VOLUME: 105

Page Numbers: 151-6

Journal Abbreviation: J. Pharmacol. Sci.

ISSN: 1347-8613

DAY: 6

MONTH: 10

YEAR: 2007

Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies. Information

Number of References: 49

LANGUAGE: eng

NlmUniqueID: 101167001

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Grant and Affiliation Information for Life style-related diseases of the digestive system: gene expression in nonalcoholic steatohepatitis patients and treatment strategies.

AFFILIATION: Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Country: Japan

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MEDLINETA: J Pharmacol Sci

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