Library of biphenyl privileged substructures using a safety-catch linker approach.

Library of biphenyl privileged substructures using a safety-catch linker approach. Research Abstract Details 

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Library of biphenyl privileged substructures using a safety-catch linker approach. Abstract Text:

A biphenyl privileged structure library containing three attachment points were synthesized using a catechol-based safety-catch linker strategy. The method requires the attachment of a bromo-acid to the linker, followed by a Pd-catalyzed Suzuki cross-coupling reaction. Further derivatization, activation of the linker with strong acid and aminolysis afforded the respective products in high purity and good overall yield. To show the versatility of the synthesis, a 199-member library was generated. The library samples both conformational and chemical diversity about a well-known privileged substructure.

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PUBMED ID PMID:

MEDLINE DATE: 2008 Jul-Aug

Library of biphenyl privileged substructures using a safety-catch linker approach. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of combinatorial chemistry

VOLUME: 10

Page Numbers: 557-66

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ISSN: 1520-4774

DAY: 8

MONTH: 05

YEAR: 2008

Library of biphenyl privileged substructures using a safety-catch linker approach. Information

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LANGUAGE: eng

NlmUniqueID: 100886263

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Grant and Affiliation Information for Library of biphenyl privileged substructures using a safety-catch linker approach.

AFFILIATION: Institute for Molecular Bioscience, The University of Queensland, St. Lucia, 4072 Queensland, Australia.

Country: United States

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MEDLINETA: J Comb Chem

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