LH-RH stimulated LH secretion in human endocrine disease.

LH-RH stimulated LH secretion in human endocrine disease. Research Abstract Details 

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LH-RH stimulated LH secretion in human endocrine disease. Abstract Text:

H Vierhapper,

The application of LH-RH provides means to describe the functional state of the hypothalamo-pituitary-gonadal axis and has helped to understand the regulation of gonadotropin secretion both under normal and pathological circumstances. At present, diagnostic LH-RH application appears to be most useful in patients with delayed puberty, where a biphasic response during an infusion of LH-RH excludes hypogonadotropic hypogonadism at an early clinical stage. An enhanced LH-RH induced response following exogenous intermittent LH-RH administration identifies the subgroup of hypogonadotropic patients who are suitable for subsequent LH-RH substitution therapy. In addition, subtle derangements of gonadotropin secretion have been described in a score of clinical conditions including the endocrine disorders discussed in this review. However, interesting as these observations may be theoretically, their practical value is often limited since a multitude of interfering factors, both exogenous and endogenous, results in a great variability in the obtained results, thus limiting the diagnostic value of the test in a specific patient. As of recently the clinical use of LH-RH includes its therapeutic application to replace low endogenous levels of LH-RH, whereas long-acting analogues of the natural decapeptide are employed to suppress gonadotropin secretion in an increasing field of endocrine disorders.

LH-RH stimulated LH secretion in human endocrine disease. Publishing Authors By Initials

H Vierhapper,

For similar endocrine system diseases: thyroid diseases research abstracts see: endocrine system diseases: thyroid diseases research

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LH-RH stimulated LH secretion in human endocrine disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta endocrinologica. Supplementum

VOLUME: 269

Page Numbers: 3-25

Journal Abbreviation:

ISSN: 0300-9750

DAY: 12

MONTH: 02

YEAR: 1985

LH-RH stimulated LH secretion in human endocrine disease. Information

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LANGUAGE: eng

NlmUniqueID: 370313

LH-RH stimulated LH secretion in human endocrine disease. Keywords Mesh Terms:

KEYWORDS: Thyroid Diseases

MESH TERMS: physiopathology

Chemical & Substance for Abstract: LH-RH stimulated LH secretion in human endocrine disease. Information

Substance Name: Follicle Stimulating Hormone

Registry Number: 9002-68-0

Grant and Affiliation Information for LH-RH stimulated LH secretion in human endocrine disease.

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Country: DENMARK

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MEDLINETA: Acta Endocrinol Suppl (Copenh)

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