Levetiracetam use in critically ill patients.

Levetiracetam use in critically ill patients. Research Abstract Details 

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Levetiracetam use in critically ill patients. Abstract Text:

Jerzy P Szaflarski,Jason M Meckler,Magdalena Szaflarski,Lori A Shutter,Michael D Privitera,Stephen L Yates,Jerzy P Szaflarski,Jason M Meckler,Magdalena Szaflarski,Lori A Shutter,Michael D Privitera,Stephen L Yates,

INTRODUCTION: Levetiracetam (LEV) is used in the setting of acute brain injury for seizure treatment or prophylaxis but its safety and efficacy in this setting is unknown. METHOD: We retrospectively analyzed the patterns of use and safety/efficacy of LEV in 379 patients treated in the neuroscience intensive care unit (NSICU). We extracted from the charts clinical data including diagnosis, AED therapy before and during stay in the NSICU, complications of treatment, length of stay, and clinical outcomes (improvement, Glasgow Coma Scale, and death). We analyzed the data using binary and ordered (multi-category) logistic regression. RESULTS: Overall, our findings are that phenytoin used prior to the NSICU admission was frequently replaced with LEV monotherapy (P < 0.001). Patients treated with LEV monotherapy when compared to other AEDs had lower complication rates and shorter NSICU stays. Older patients and patients with brain tumors or strokes were preferentially treated with LEV for prevention and/or management of seizures (all P < or = 0.014). DISCUSSION: The results of this study suggest that LEV is a frequently used AED in the setting of acute brain injury and that it may be a desirable alternative to phenytoin. Prospective studies evaluating the long-term safety, efficacy and outcomes of LEV in this setting are indicated.

Levetiracetam use in critically ill patients. Publishing Authors By Initials

JP Szaflarski,JM Meckler,M Szaflarski,LA Shutter,MD Privitera,SL Yates,JP Szaflarski,JM Meckler,M Szaflarski,LA Shutter,MD Privitera,SL Yates,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Levetiracetam use in critically ill patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurocritical care

VOLUME: 7

Page Numbers: 140-7

Journal Abbreviation:

ISSN: 1541-6933

DAY: 14

MONTH: 12

YEAR: 2007

Levetiracetam use in critically ill patients. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101156086

Levetiracetam use in critically ill patients. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: mortality

Chemical & Substance for Abstract: Levetiracetam use in critically ill patients. Information

Substance Name: Piracetam

Registry Number: 7491-74-9

Grant and Affiliation Information for Levetiracetam use in critically ill patients.

AFFILIATION: Department of Neurology, University of Cincinnati Medical Center, MSB Rm. 4506, ML 0525, 231 Albert B. Sabin Way, Cincinnati, OH 45267-0525, USA. Jerzy.Szaflarski@uc.edu

Country: United States

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MEDLINETA: Neurocrit Care

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