Levels of GFR and protein-induced hyperfiltration in kidney donors: a single-center experience in India.

Levels of GFR and protein-induced hyperfiltration in kidney donors: a single-center experience in India. Research Abstract Details 

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Levels of GFR and protein-induced hyperfiltration in kidney donors: a single-center experience in India. Abstract Text:

Sukanta Barai,Sanjay Gambhir,Narayan Prasad,Raj Kumar Sharma,Manish Ora,Alok Kumar,Amit Gupta,Deep Shankar Parasar,Batchu Suneetha,

BACKGROUND: Some studies have shown that the normal range of glomerular filtration rate (GFR) was lower in an Indian population than in western populations. To verify these findings and determine whether it is physiological or an expression of subclinical disease, we measured GFR in a cohort of healthy Indian adults by using more stringent criteria to define "healthy" than used in previous studies. STUDY DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: 109 healthy adults being evaluated for kidney donation with normal blood pressure, body mass index, urinalysis results, and protein excretion and symmetrical function on radionuclide renogram. Subjects followed a vegetarian diet with 1 g/kg of protein intake for 10 days before the study. PREDICTORS: Age, sex, relation to recipient (relative versus spouse), body surface area, body mass index, kidney size, serum creatinine level, and urinary protein-creatinine ratio. OUTCOME AND MEASUREMENTS: GFR measured as plasma clearance of technetium 99m diethyl-triamine-penta-acetic acid before and after amino-acid infusion (protein-induced hyperfiltration). Measurements were performed after a 12-hour fast. RESULTS: Mean baseline GFR was 82.4 +/-12.7 mL/min/1.73 m(2) (95% confidence interval, 80.0 to 84.8). Mean stimulated GFR was 104.7 +/- 16.1 mL/min/1.73 m(2) (95% confidence interval, 101.6 to 107.8). Measured mean protein-induced hyperfiltration was 27.3% +/- 10.04% (range, 6.7% to 56%). In multivariable linear regression analysis, younger age, spousal donor, and larger average kidney size were associated with significantly greater baseline GFR, and only greater baseline GFR was associated significantly with stimulated GFR. LIMITATIONS: Dietary protein intake was not measured; a habitual low-protein diet cannot be excluded as a cause of low GFR. CONCLUSIONS: Basal GFR is significantly lower than the normal value of 120 to 130 mL/min/1.73 m(2) in western populations. The conventional cutoff value of 60 mL/min/1.73 m(2) for defining chronic kidney disease might not be appropriate in India.

Levels of GFR and protein-induced hyperfiltration in kidney donors: a single-center experience in India. Publishing Authors By Initials

S Barai,S Gambhir,N Prasad,RK Sharma,M Ora,A Kumar,A Gupta,DS Parasar,B Suneetha,

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Levels of GFR and protein-induced hyperfiltration in kidney donors: a single-center experience in India. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of kidney diseases : the official

VOLUME: 51

Page Numbers: 407-14

Journal Abbreviation: Am. J. Kidney Dis.

ISSN: 1523-6838

DAY: 25

MONTH: Mar

YEAR: 2008

Levels of GFR and protein-induced hyperfiltration in kidney donors: a single-center experience in India. Information

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LANGUAGE: eng

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AFFILIATION: Department of Nuclear Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. danzig@rediffmail.com

Country: United States

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MEDLINETA: Am J Kidney Dis

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