Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study.

Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study. Abstract Text:

Lisa M Pierce,Shannon Baumann,Michelle R Rankin,Richard M Wasserman,Arabella Biaggi,Thomas J Kuehl,Kimberly W Coates,

OBJECTIVE: This study was undertaken to evaluate histologically the levator ani muscle and paravaginal attachments in squirrel monkeys with and without pelvic organ prolapse. STUDY DESIGN: Serial sections from 19 females were processed with routine histology stains. Fiber typing was performed with antifast (type II) and antislow (type I) skeletal myosin antibodies, and apoptotic nuclei were examined by dUTP nick-end labeling (TUNEL). RESULTS: Gross disruption of the levator ani muscle and its innervation was not observed in animals with or without visible support defects. Myogenic changes occurred more frequently in the pubocaudalis than iliocaudalis muscles, and a significant association was found with aging (P < .05, Fisher exact test) but not with pelvic organ prolapse or parity. Neurogenic changes were observed in 3 of 13 multiparous monkeys. Myocyte diameter increased in animals with pelvic organ prolapse compared with age-, weight-, and parity-matched animals without pelvic organ prolapse (P = .005) and correlated with levator ani muscle wet weight (R = 0.76; P = .0006). In the paravaginal attachments, the numbers of fibroblasts and apoptotic nuclei were not different between animals with and without pelvic organ prolapse, but parity was associated with increased apoptosis (P = .025). CONCLUSION: Vaginal prolapse in the squirrel monkey does not result from atrophy or gross disruption of the levator ani muscle or its innervation. As in women, myogenic changes are a common finding in the levator ani muscle and increase with aging, whereas denervation with subsequent reinnervation occurs in some multiparous monkeys.

Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study. Publishing Authors By Initials

LM Pierce,S Baumann,MR Rankin,RM Wasserman,A Biaggi,TJ Kuehl,KW Coates,

For similar female urogenital diseases and pregnancy complications: female urogenital diseases: genital diseases, female: uterine diseases: uterine prolapse research abstracts see: female urogenital diseases and pregnancy complications: female urogenital diseases: genital diseases, female: uterine diseases: uterine prolapse research

PUBMED ID PMID:

MEDLINE DATE:

Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of obstetrics and gynecology

VOLUME: 197

Page Numbers: 60.e1-9

Journal Abbreviation: Am. J. Obstet. Gynecol.

ISSN: 1097-6868

DAY: 3

MONTH: Jul

YEAR: 2007

Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370476

Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study. Keywords Mesh Terms:

KEYWORDS: Uterine Prolapse

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study.

AFFILIATION: Department of Obstetrics and Gynecology, Scott & White Hospital, Temple, TX 76508, USA. lpierce@swmail.sw.org

Country: United States

AGENCY: United States NICHD

GRANT: HD 38655

ACRONYM: HD

MEDLINETA: Am J Obstet Gynecol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study Related Publications

• 16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana.
• A new time-scale for ray-finned fish evolution.
• Alkaline iron(III) reduction by a novel alkaliphilic, halotolerant, Bacillus sp. isolated from salt flat sediments of Soap Lake.
• Association between reproductive factors and breast cancer survival in younger women.
• Carbonylation of Epoxides to Substituted 3-Hydroxy-delta-Lactones.
• Factors associated with advanced disease stage at diagnosis in a population-based study of patients with newly diagnosed breast cancer.
• General and abdominal obesity and survival among young women with breast cancer.
• High-activity, single-site catalysts for the alternating copolymerization of CO2 and propylene oxide.
• Implementation and evaluation of an HIV/STD intervention in Peru.
• Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate.
• Jejuno-gastric intussusception.
• Levator ani muscle and connective tissue changes associated with pelvic organ prolapse, parity, and aging in the squirrel monkey: a histologic study.
• Main drainage in relation to housing development.
• Oral contraceptives and survival in breast cancer patients aged 20 to 54 years.
• Pain and the surgeon.
• Preliminary neutron and ultrahigh-resolution X-ray diffraction studies of the aspartic proteinase endothiapepsin cocrystallized with a gem-diol inhibitor.
• Prevalence of bacterial vaginosis among young women in low-income populations of coastal Peru.
• Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98.
• Quality of life and quality-adjusted survival (Q-TWiST) in patients receiving dose-intensive or standard dose chemotherapy for high-risk primary breast cancer.
• Quantifying ammonia emissions from a cattle feedlot using a dispersion model.
• Recreational physical activity and survival among young women with breast cancer.
• Silver Medal Recipient 2007 - DR DUDLEY HILL.
• Surgery in ulcerative colitis.
• Synthesis of beta-lactones: a highly active and selective catalyst for epoxide carbonylation.
• The CARI guidelines. Calcineurin inhibitors in renal transplantation: nephrotoxicity and calcineurin inhibitors.
• The Dioxanone Approach to (2S,3R)-2-C-Methylerythritol 4-Phosphate and 2,4-Cyclodiphosphate, and Various MEP Analogues.
• The chemistry of phosphorus insecticides.
• Uremia impairs monocyte and monocyte-derived dendritic cell function in hemodialysis patients.
• ent-Beyerane diterpenoids from the heartwood of Excoecaria parvifolia.
• p53 and Mdm2: not all cells are equal.