Leukotrienes: mediators that have been typecast as villains.

Leukotrienes: mediators that have been typecast as villains. Research Abstract Details 

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Leukotrienes: mediators that have been typecast as villains. Abstract Text:

N Flamand,P Mancuso,C H C Serezani,T G Brock,N Flamand,P Mancuso,C H C Serezani,T G Brock,

As befalls many mediators that act upon the human stage, leukotrienes have become identified with their most powerful roles as villains of the immune system. They are well known for their leading roles in allergic diseases, including asthma. They also have gained recognition for their dramatic role as promoters of inflammation. As new roles for these lipid messengers are sought, it is becoming apparent that the leukotrienes have been typecast as bad guys of the immune system. As examples, their more recent roles have been in atherosclerosis, pulmonary fibrosis and cancer. However, upon further evaluation, we can begin to see their versatility. Thus, leukotrienes stimulate innate immunity against pathogens. In addition, they promote the expression of mediators, receptors and other molecules that are important for immune defense. In these lesser known roles, they lead the fight against bacterial, fungal and viral infection. This review is intended to shed light on the leukotrienes, where they come from and what we really know about them.

Leukotrienes: mediators that have been typecast as villains. Publishing Authors By Initials

N Flamand,P Mancuso,CH Serezani,TG Brock,N Flamand,P Mancuso,CH Serezani,TG Brock,

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Leukotrienes: mediators that have been typecast as villains. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular and molecular life sciences : CMLS

VOLUME: 64

Page Numbers: 2657-70

Journal Abbreviation: Cell. Mol. Life Sci.

ISSN: 1420-682X

DAY: 30

MONTH: Oct

YEAR: 2007

Leukotrienes: mediators that have been typecast as villains. Information

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LANGUAGE: eng

NlmUniqueID: 9705402

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Grant and Affiliation Information for Leukotrienes: mediators that have been typecast as villains.

AFFILIATION: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Country: Switzerland

AGENCY: United States NHLBI

GRANT: HL077417

ACRONYM: HL

MEDLINETA: Cell Mol Life Sci

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