Leukoreduction filtration of whole-blood units from sickle trait donors: effects of a metered citrate anticoagulant system.

Leukoreduction filtration of whole-blood units from sickle trait donors: effects of a metered citrate anticoagulant system. Research Abstract Details 

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Leukoreduction filtration of whole-blood units from sickle trait donors: effects of a metered citrate anticoagulant system. Abstract Text:

Barbara J Bryant,Maria Bianchi,Robert A Wesley,David F Stroncek,Susan F Leitman,Barbara J Bryant,Maria Bianchi,Robert A Wesley,David F Stroncek,Susan F Leitman,

BACKGROUND: Polymerization of hemoglobin (Hb) S is exacerbated by acidic and hyperosmotic citrate anticoagulant solutions and often results in occlusion of leukoreduction filters by red blood cells (RBCs) from sickle cell trait (Hb AS) donors. This study evaluates a blood collection instrument that adds citrate anticoagulant in a metered fashion, thus mitigating adverse citrate effects. STUDY DESIGN AND METHODS: Collection of whole blood by a metered anticoagulant system was compared to traditional phlebotomy in 12 Hb AS and 12 non-sickle trait (Hb AA) donors. Each donated twice; on one occasion, units were filtered after 4-hour storage at 20 to 24 degrees C, and on the other, units were stored at 1 to 6 degrees C for 24 hours before filtration. RESULTS: Filtration times, RBC recoveries, and residual white blood cell (WBC) counts met defined criteria more often in Hb AS units collected by a metered anticoagulant system (9 of 12, 8 of 12, and 4 of 12, respectively) compared to traditional phlebotomy (1 of 12, 2 of 12, and 0 of 12, respectively). Overall, Hb AS units filtered better after storage at 1 to 6 degrees C for 24 hours, with units collected by a metered anticoagulant system undergoing filtration most effectively (5 of 6 had >85% RBC recovery, 3 of 6 had <5 x 10(6) residual WBC). Units exhibited similar changes in RBC storage parameters. CONCLUSION: Use of a metered anticoagulation instrument demonstrates potential for successful leukoreduction and acceptable storage of Hb AS units; however, the system needs further modifications and improvements before it can be utilized to collect and leukoreduce Hb AS blood.

Leukoreduction filtration of whole-blood units from sickle trait donors: effects of a metered citrate anticoagulant system. Publishing Authors By Initials

BJ Bryant,M Bianchi,RA Wesley,DF Stroncek,SF Leitman,BJ Bryant,M Bianchi,RA Wesley,DF Stroncek,SF Leitman,

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Leukoreduction filtration of whole-blood units from sickle trait donors: effects of a metered citrate anticoagulant system. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transfusion

VOLUME: 47

Page Numbers: 2233-41

Journal Abbreviation: Transfusion

ISSN: 0041-1132

DAY: 21

MONTH: 08

YEAR: 2007

Leukoreduction filtration of whole-blood units from sickle trait donors: effects of a metered citrate anticoagulant system. Information

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LANGUAGE: eng

NlmUniqueID: 417360

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AFFILIATION: Department of Transfusion Medicine and the Department of Biostatistics Services, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

Country: United States

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MEDLINETA: Transfusion

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