Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice.

Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Research Abstract Details 

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Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Abstract Text:

Lange-Sperandio,Agnes Trautmann,Oliver Eickelberg,Aparna Jayachandran,Stephan Oberle,Florian Schmidutz,Barbara Rodenbeck,Meike ,Richard Horuk,Franz Schaefer, Lange-Sperandio,Agnes Trautmann,Oliver Eickelberg,Aparna Jayachandran,Stephan Oberle,Florian Schmidutz,Barbara Rodenbeck,Meike ,Richard Horuk,Franz Schaefer,

Urinary tract obstruction during renal development leads to tubular apoptosis, tubular atrophy, and interstitial fibrosis. Epithelial to mesenchymal transition (EMT) has been proposed as a key mechanism of myofibroblast accumulation in renal fibrosis. We studied the interplay of leukocyte infiltration, tubular apoptosis, and EMT in renal fibrosis induced by unilateral ureteral obstruction (UUO) in neonatal mice. We show that leukocytes mediate tubular apoptosis and EMT in the developing kidney with obstructive nephropathy. Blocking leukocyte recruitment by using the chemokine receptor-1 antagonist BX471 protected against tubular apoptosis and interstitial fibrosis, as evidenced by reduced monocyte influx, a decrease in EMT, and attenuated collagen deposition. EMT was rapidly induced within 24 hours after UUO along with up-regulation of the transcription factors Snail1 and Snail2/Slug, preceding the induction of alpha-smooth muscle actin and vimentin. In the presence of BX471, the expression of chemokines, as well as of Snail1 and Snail2/Slug, in the obstructed kidney was completely attenuated. This was associated with reduced macrophage and T-cell infiltration, tubular apoptosis, and interstitial fibrosis in the developing kidney. Our findings provide evidence that leukocytes induce EMT and renal fibrosis after UUO and suggest that chemokine receptor-1 antagonism may prove beneficial in obstructive nephropathy.

Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Publishing Authors By Initials

B Lange-Sperandio,A Trautmann,O Eickelberg,A Jayachandran,S Oberle,F Schmidutz,B Rodenbeck,M ,R Horuk,F Schaefer,B Lange-Sperandio,A Trautmann,O Eickelberg,A Jayachandran,S Oberle,F Schmidutz,B Rodenbeck,M ,R Horuk,F Schaefer,

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Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of pathology

VOLUME: 171

Page Numbers: 861-71

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 3

MONTH: 08

YEAR: 2007

Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Information

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LANGUAGE: eng

NlmUniqueID: 370502

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AFFILIATION: Department of Pediatrics, Ruprecht-Karls-University, Heidelberg, Germany. baerbel.lange-sperandio@med.uni-muenchen.de

Country: United States

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MEDLINETA: Am J Pathol

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