Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions.

Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Research Abstract Details 

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Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Abstract Text:

It has been proposed that HIV-1, in addition to directly infecting and killing CD4+ T cells, causes T cell dysfunction and T cell loss by chronic immune activation. We analyzed the effects of chronic immune activation in mice that constitutively expressed CD70, the ligand for the tumor necrosis factor receptor family member CD27, on B cells. CD70 transgenic (CD70 Tg) mice showed a progressive conversion of naive T cells into effector-memory cells, which culminated in the depletion of naive T cells from lymph nodes and spleen. T cell changes depended on continuous CD27-CD70 interactions and T cell antigen receptor stimulation. Despite this hyperactive immune system, CD70 Tg mice died aged 6-8 months from Pneumocystis carinii infection, a hallmark of T cell immunodeficiency. Thus, persistent delivery of costimulatory signals via CD27-CD70 interactions, as may occur during chronic active viral infections, can exhaust the T cell pool and is sufficient to induce lethal immunodeficiency.

Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Publishing Authors By Initials

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature immunology

VOLUME: 4

Page Numbers: 49-54

Journal Abbreviation: Nat. Immunol.

ISSN: 1529-2908

DAY: 9

MONTH: 12

YEAR: 2002

Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Information

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LANGUAGE: eng

NlmUniqueID: 100941354

Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: pathology

Chemical & Substance for Abstract: Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Information

Substance Name: Tnfsf7 protein, mouse

Registry Number: 0

Grant and Affiliation Information for Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions.

AFFILIATION: Laboratory for Experimental Immunology, Academic Medical Center, P.O. Box 22700, 1100DD Amsterdam, The Netherlands.

Country: United States

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MEDLINETA: Nat Immunol

REFSOURCE: Nat Immunol. 2003 Mar;4(3):295

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