Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction.

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Abstract Text:

Linley E Watson,Jonathan Mock,Hind Lal,Guangrong Lu,Raymond W Bourdeau,Wei-Jen Tang,Stephen H Leppla,David E Dostal,Arthur E Frankel,

Fatalities due to anthrax are associated with severe hypotension suggesting that the toxins generated from Bacillus anthracis, lethal toxin (LeTx) and edema toxin (EdTx), have cardiovascular effects. Here, we demonstrate the effects of these toxins and characterize their effects by echocardiography. LeTx leads to a significant reduction in ejection fraction, decreased velocity of propagation (diastolic dysfunction), decreased velocity of circumferential fiber shortening (decreased contractility), and increased LV systolic area (pathophysiology). EdTx leads to a significant reduction in left ventricular volumes and cardiac output (reduced stroke volume) but does not cause significant change in ejection fraction or contractility. These results indicate that LeTx reduces left ventricular systolic function and EdTx reduces preload but does not have direct myocardial effects. Together, these findings suggest that LeTx and EdTx exert distinct hemodynamic dysfunction associated with anthrax infection.

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Publishing Authors By Initials

LE Watson,J Mock,H Lal,G Lu,RW Bourdeau,WJ Tang,SH Leppla,DE Dostal,AE Frankel,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

PUBMED ID PMID:

MEDLINE DATE:

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 12

Page Numbers: 4670-5

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 05

YEAR: 2007

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9709506

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: physiology

Chemical & Substance for Abstract: Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction. Information

Substance Name: Adenylate Cyclase

Registry Number: EC 4.6.1.1

Grant and Affiliation Information for Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction.

AFFILIATION: Division of Cardiology, Scott and White Memorial Hospital, Scott, Sherwood and Brindley Foundation and Cardiovascular Research Institute, Texas A & M University System, Health Science Center College of Medicine, Temple, TX 76502, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL68838

ACRONYM: HL

MEDLINETA: Front Biosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction Related Publications

• A self-propagating structural change in Triticum; duplication and crossing-over.
• A truncated Bacillus subtilis dal gene with a 3' ssrA gene tag regulates the growth and virulence of racemase-deficient Listeria monocytogenes.
• Adherence of enterohemorrhagic Escherichia coli O157, O26, and O111 strains to bovine intestinal explants ex vivo.
• Arginase activity and nitrogen content in epidermal carcinogenesis in mice.
• Asymptomatic hemorrhagic transformation of cerebral infarction does not worsen long-term outcome.
• Cell attachment properties and infectivity of host-adapted and environmentally adapted Citrobacter rodentium.
• Churchmen famous in medicine.
• Clinical characteristics of patients with early hospital arrival after stroke symptom onset.
• Complex seizure disorder caused by Brunol4 deficiency in mice.
• Diagnosis and treatment of carpal injuries.
• Double immunohistochemical staining with MUC4/p53 is useful in the distinction of pancreatic adenocarcinoma from chronic pancreatitis: a tissue microarray-based study.
• Enteropathogenic Escherichia coli O125:H6 triggers attaching and effacing lesions on human intestinal biopsy specimens independently of Nck and TccP/TccP2.
• Escherichia coli serogroup O26 - a new look at an old adversary.
• Fatal aplastic anemia during anti-convulsant therapy; report of a case during phenurone therapy and following mesantoin therapy.
• Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism.
• Heart rate of pet dogs: effects of overweight and exercise.
• Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction.
• Local anesthesia for inguinal hernia repair in adolescents.
• Numerical simulation of turbulence transition and sound radiation for flow through a rigid glottal model.
• Overdose of amphetamine.
• Pancreatic Endocrine Tumors-c-erb B2 (Her-2/neu), bcl-2, and p-53 Immunohistochemical Testing and Their Value in Assessing Prognosis.
• Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinzatrade mark, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer.
• Statistical research in the cancer program in New Jersey.
• Stromal osteonectin overexpression is associated with poor outcome in patients with ampullary cancer.
• TccP2-mediated subversion of actin dynamics by EPEC 2 - a distinct evolutionary lineage of enteropathogenic Escherichia coli.
• The Lactobacillus acidophilus count as an aid to caries control.
• The preparation and condensation polymerization of higher alkyl esters of alpha-amino acids.
• The treatment of intertrochanteric fractures.
• Urea and ammonia content of mouse epidermis.
• Use of unstructured parent narratives to evaluate medical student competencies in communication and professionalism.