Lesions of the medial prefrontal cortex prevent the acquisition but not reinstatement of morphine-induced conditioned place preference in mice.

Lesions of the medial prefrontal cortex prevent the acquisition but not reinstatement of morphine-induced conditioned place preference in mice. Research Abstract Details 

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Lesions of the medial prefrontal cortex prevent the acquisition but not reinstatement of morphine-induced conditioned place preference in mice. Abstract Text:

Yue Hao,Jingyu Yang,Jiye Sun,Jia Qi,Yingxu Dong,Chun Fu Wu,Yue Hao,Jingyu Yang,Jiye Sun,Jia Qi,Yingxu Dong,Chun Fu Wu,

In order to further investigate the role of the mPFC in morphine reward and drug priming induced relapse, the present study examined the effects of the mPFC lesions on the acquisition and morphine priming induced reinstatement of conditioned place preference (CPP). In the first experiment, mice received sham or bilateral kainic acid lesions of the mPFC and were subsequently tested for the acquisition of a morphine-induced CPP. In the second experiment, each mouse received lesions of mPFC following the establishment of morphine-induced CPP. Nine days later, a priming injection of morphine was given (2mg/kg, i.p.) to reinstate the extinguished CPP. The results showed that pre-conditioning lesions of the mPFC blocked the acquisition of morphine-induced CPP, while post-conditioning lesions of the mPFC failed to prevent morphine priming induced reinstatement of CPP. These results provide the first direct evidence that the mPFC may be involved in the acquisition, but not morphine priming induced reinstatement of CPP.

Lesions of the medial prefrontal cortex prevent the acquisition but not reinstatement of morphine-induced conditioned place preference in mice. Publishing Authors By Initials

Y Hao,J Yang,J Sun,J Qi,Y Dong,CF Wu,Y Hao,J Yang,J Sun,J Qi,Y Dong,CF Wu,

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Lesions of the medial prefrontal cortex prevent the acquisition but not reinstatement of morphine-induced conditioned place preference in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroscience letters

VOLUME: 433

Page Numbers: 48-53

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 5

MONTH: Mar

YEAR: 2008

Lesions of the medial prefrontal cortex prevent the acquisition but not reinstatement of morphine-induced conditioned place preference in mice. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Lesions of the medial prefrontal cortex prevent the acquisition but not reinstatement of morphine-induced conditioned place preference in mice.

AFFILIATION: Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.

Country: Ireland

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MEDLINETA: Neurosci Lett

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