Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning.

Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Research Abstract Details 

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Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Abstract Text:

The contribution of the basal forebrain cholinergic system in mediating plasticity of cortical sensorimotor representations was examined in the context of normal learning. The effects of specific basal forebrain cholinergic lesions upon cortical reorganization associated with learning a skilled motor task were investigated, addressing, for the first time, the functional consequences of blocking cortical map plasticity. Results demonstrate that disrupting basal forebrain cholinergic function disrupts cortical map reorganization and impairs motor learning. Cholinergic lesions do not impair associative fear learning or overall sensorimotor function. These results support the hypothesis that the basal forebrain cholinergic system may be specifically implicated in forms of learning requiring plasticity of cortical representations.

Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Publishing Authors By Initials

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Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuron

VOLUME: 38

Page Numbers: 819-29

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 5

MONTH: Jun

YEAR: 2003

Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Information

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LANGUAGE: eng

NlmUniqueID: 8809320

Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Keywords Mesh Terms:

KEYWORDS: Ribosome Inactivating Proteins, Type 1

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Information

Substance Name: saporin

Registry Number: EC 3.2.2.22

Grant and Affiliation Information for Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning.

AFFILIATION: Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA. jmconner@ucsd.edu

Country: United States

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MEDLINETA: Neuron

REFSOURCE: Neuron. 2003 Jun 5;38(5):678-80

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