Leptin in morbidly obese patients: no role for treatment of morbid obesity but important in the postoperative immune response.

Leptin in morbidly obese patients: no role for treatment of morbid obesity but important in the postoperative immune response. Research Abstract Details 

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Leptin in morbidly obese patients: no role for treatment of morbid obesity but important in the postoperative immune response. Abstract Text:

Jeroen Nijhuis,Francois M H Van Dielen,Wim A Buurman,Jan Willem M Greve,

Despite the current opinion that leptin can no longer be seen as a hormone which could be used therapeutically to prevent an energy surplus (it rather protects the organism for an energy deficit), leptin may still have an impact in clinical medicine. Leptin was shown to have several important functions. The pleiotropic properties of leptin include a regulatory function in the immune system. Reviewing the effects of leptin on different parts of the immune system reveals that the immune system is deregulated in an environment low in leptin. A strong reduction in leptin levels occurs in situations of starvation as seen after bariatric surgery. We postulate the hypothesis that the starvation-induced postoperative decrease of leptin is causative of the more serious course of complications observed after bariatric surgery.

Leptin in morbidly obese patients: no role for treatment of morbid obesity but important in the postoperative immune response. Publishing Authors By Initials

J Nijhuis,FM Van Dielen,WA Buurman,JW Greve,

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Leptin in morbidly obese patients: no role for treatment of morbid obesity but important in the postoperative immune response. Journal Published:

PUBLICATION TYPE: Review

Journal: Obesity surgery

VOLUME: 14

Page Numbers: 476-83

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ISSN: 0960-8923

DAY: 5

MONTH: Apr

YEAR: 2004

Leptin in morbidly obese patients: no role for treatment of morbid obesity but important in the postoperative immune response. Information

Number of References: 70

LANGUAGE: eng

NlmUniqueID: 9106714

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AFFILIATION: Department of General Surgery, Maastricht University, the Netherlands. jeroen.nijhuis@ah.unimaas.nl

Country: Canada

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MEDLINETA: Obes Surg

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