Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy.

Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy. Abstract Text:

Recent in vitro and in vivo studies emphasize the impact of leptin, peroxisome proliferator-activated receptors (PPAR) and PPAR coactivators (retinoic X receptor a (RXR), amplified in breast cancer-3 gene (AIB3)) on placental and fetal development. Therefore, the frequency and distribution pattern of PPAR, RXR, AIB3 and leptin expression in normal human first trimester pregnancy, miscarriage and hydatidiform mole was investigated by immunohistochemistry and double immunofluorescence staining. Enhanced expression of PPAbeta/delta, RXR and AIB3 was identified in miscarried placentas. With regard to hydatidiform mole, increased expression of PPARgamma and PPARbeta/delta was observed, whereas RXR was significantly down-regulated. Leptin expression was lowest in miscarriage and highest in mole pregnancies. In contrast to trophoblast tissue, expression of leptin in glandular epithelial cells of the decidua was increased in miscarriage. PPAR and leptin expressing cells at the feto-maternal interface were identified as extravillous trophoblast (EVT) by double immunofluorescence and CK7 staining. In summary, significantly reduced leptin expression was accompanied by enhanced PPARbeta/delta, RXR and AIB3 expression in miscarried placentas. However, in mole pregnancy, up-regulation of leptin and increased expression of PPAR was detected. RXR, on the other hand, was down-regulated in mole decidua. So far, the study results implicate strong regulatory interaction of PPARs, their coactivators and leptin in human placentas. PPAR and leptin are potential targets for new treatment strategies concerning pregnancy disorders, such as miscarriage. The increasing knowledge about the role of PPARs and leptin in normal and disturbed pregnancy may help to improve pregnancy outcome.

Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Histology and histopathology

VOLUME: 23

Page Numbers: 1465-75

Journal Abbreviation: Histol. Histopathol.

ISSN: 1699-5848

DAY: 2

MONTH: Dec

YEAR: 2008

Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8609357

Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy.

AFFILIATION: Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, Grosshadern, Munich, Germany.

Country: Spain

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Histol Histopathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy Related Publications

• A pulsed EPR study of surfactant layer structure in composites of a synthetic layered silicate with polystyrene and polycaprolactone.
• Amnion in the treatment of pediatric partial-thickness facial burns.
• Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive?
• Erythropoietin and erythropoietin receptor expression in normal and disturbed pregnancy.
• Expression of the carbohydrate tumour marker SLeX, SLeA (CA19-9), LeY and Thomsen-Friedenreich (TF) antigen on normal squamous epithelial tissue of the penis and vagina.
• Gene therapy in wound healing: present status and future directions.
• Glycodelin protein and mRNA is downregulated in human first trimester abortion and partially upregulated in mole pregnancy.
• High-resolution structure of a Na+/H+ antiporter dimer obtained by pulsed electron paramagnetic resonance distance measurements.
• Human umbilical vascular endothelial cells express estrogen receptor beta (ERbeta) and progesterone receptor A (PR-A), but not ERalpha and PR-B.
• Inhalation injury in severely burned children does not augment the systemic inflammatory response.
• Insulin attenuates apoptosis and exerts anti-inflammatory effects in endotoxemic human macrophages.
• Insulin attenuates the cytokine response in a burn wound infection model.
• Leptin and peroxisome proliferator-activated receptors: impact on normal and disturbed first trimester human pregnancy.
• Longitudinal assessment of Integra in primary burn management: a randomized pediatric clinical trial.
• Peroxisome proliferator-activated receptors: new players in the field of reproduction.
• Photo-CIDNP MAS NMR beyond the T(1) limit by fast cycles of polarization extinction and polarization generation.
• Relaxation-based distance measurements between a nitroxide and a lanthanide spin label.
• Second hit post burn increased proximal gut mucosa epithelial cells damage.
• Serum cytokine differences in severely burned children with and without sepsis.
• Stabilization of microvascular pedicles in intricate locations using fibrin glue.
• The factor age and the recovery of severely burned children.
• Urinary cortisol and catecholamine excretion after burn injury in children.
• [Hemodynamics and ergometric performance modified by low dosage oral contraceptives]
• [Investigations on regulation of CRH, ACTH and cortisol in trophoblast cells in vitro]
• [Problems in the discontinuation of sterility treatment]