Left ventricular contractile state after surgical correction of tetralogy of Fallot: risk factors for late left ventricular dysfunction.

Left ventricular contractile state after surgical correction of tetralogy of Fallot: risk factors for late left ventricular dysfunction. Research Abstract Details 

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Left ventricular contractile state after surgical correction of tetralogy of Fallot: risk factors for late left ventricular dysfunction. Abstract Text:

G Hausdorf,C Hinrichs,C A Nienaber,C Schark,E W Keck,

The purpose of this study was to analyze potential "risk-factors" for late left ventricular dysfunction after surgical correction of Fallot's tetralogy (FT). As the ejection-phase indices cannot distinguish abnormalities of contractility from altered loading conditions, the slope values of the end-systolic pressure-length and stress-shortening relationships were analyzed by increasing afterload. Thirty-two patients were studied after surgical correction of FT in infancy. The age at investigation was 19.2 +/- 5.6 years, total correction had been performed at the age of 7.7 +/- 3.3 years. In 20 patients a one-stage operation was performed, and in 12 patients a two-stage correction. The control group consisted of 30 healthy volunteers, aged 18-30 years. The following potential risk factors for left ventricular dysfunction were evaluated: one-stage vs. two-stage correction, age at total correction, preoperative systemic oxygen saturation, preoperative hematocrit, occurrence of hypoxic spells, preoperative ratio of left-to-right ventricular peak systolic pressure, and preoperative ratio of left-to-right ventricular end-diastolic volume. In most patients the baseline data for end-systolic wall stress lay outside the normal range, indicating abnormal loading conditions. Thus, analysis of load-independent indices of the contractile state seems to be mandatory in these patients. Our data show that the severity of preoperative hypoxemia is an important risk factor for late dysfunction of the left ventricle (p less than 0.01). Additionally, the relation of left and right ventricular peak systolic pressures and end-diastolic volumes were related to the contractile state (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Left ventricular contractile state after surgical correction of tetralogy of Fallot: risk factors for late left ventricular dysfunction. Publishing Authors By Initials

G Hausdorf,C Hinrichs,CA Nienaber,C Schark,EW Keck,

For similar cardiovascular diseases: cardiovascular abnormalities: heart defects, congenital: tetralogy of fallot research abstracts see: cardiovascular diseases: cardiovascular abnormalities: heart defects, congenital: tetralogy of fallot research

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Left ventricular contractile state after surgical correction of tetralogy of Fallot: risk factors for late left ventricular dysfunction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric cardiology

VOLUME: 11

Page Numbers: 61-8

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 20

MONTH: Apr

YEAR: 1990

Left ventricular contractile state after surgical correction of tetralogy of Fallot: risk factors for late left ventricular dysfunction. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

Left ventricular contractile state after surgical correction of tetralogy of Fallot: risk factors for late left ventricular dysfunction. Keywords Mesh Terms:

KEYWORDS: Tetralogy of Fallot

MESH TERMS: surgery

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Grant and Affiliation Information for Left ventricular contractile state after surgical correction of tetralogy of Fallot: risk factors for late left ventricular dysfunction.

AFFILIATION: Department of Pediatric Cardiology, University Hospital Hamburg, FRG.

Country: UNITED STATES

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MEDLINETA: Pediatr Cardiol

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