Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo.

Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo. Research Abstract Details 

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Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo. Abstract Text:

J Beuth,H L Ko,H Schroten,J Sölter,G Uhlenbruck,G Pulverer,

According to our hypothesis, bacterial lectins play an important role in the organotropy of infectious diseases which is analogous to the metastasis of tumor cells. As a model for proving this, we investigated the specific lectin of Streptococcus pneumoniae, which has N-acetyl-D-glucosamine/D-galactose (GlcNAc-Gal) specificity. In vitro, after incubation with Streptococcus pneumoniae, cryotome sections of various organs from Balb/c-mice showed remarkable quantitative differences of bacterial adhesion to the organ cells. Whereas lungs and meninges were closely settled with bacteria, attachment to other organs (e.g. liver, spleen, brain) was lacking. In vitro lectin-blocking by GlcNAc completely prevented the adherence of Streptococcus pneumoniae to lungs and meninges. Other non-related carbohydrates (e.g. D-mannose, D-xylose) showed no effect. During in vivo experiments with Balb/c-mice, intratracheal application of Streptococcus pneumoniae led to a diffuse settlement of the lung. However, bacterial lectin-blocking with intratracheal GlcNAc administration completely inhibited adhesion to the organ cells of the lung. Therefore blocking of bacterial adhesins with competitive specific monosaccharides can completely prevent bacterial adhesion processes, a fact, which opens therapeutical aspects.

Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo. Publishing Authors By Initials

J Beuth,HL Ko,H Schroten,J Sölter,G Uhlenbruck,G Pulverer,

For similar bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pneumoniae research abstracts see: bacteria: gram-positive bacteria: gram-positive cocci: streptococcaceae: streptococcus: streptococcus pneumoniae research

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Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zentralblatt für Bakteriologie, Mikrobiologie, und

VOLUME: 265

Page Numbers: 160-8

Journal Abbreviation:

ISSN: 0176-6724

DAY: 12

MONTH: Jun

YEAR: 1987

Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 8403032

Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo. Keywords Mesh Terms:

KEYWORDS: Streptococcus pneumoniae

MESH TERMS: metabolism

Chemical & Substance for Abstract: Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo. Information

Substance Name: Lectins

Registry Number: 0

Grant and Affiliation Information for Lectin mediated adhesion of Streptococcus pneumoniae and its specific inhibition in vitro and in vivo.

AFFILIATION: Institute of Hygiene, University of Cologne, Federal Republic of Germany.

Country: GERMANY, WEST

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MEDLINETA: Zentralbl Bakteriol Mikrobiol

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