The striatum and hippocampus are conventionally viewed as complementary learning and memory systems, with the hippocampus specialized for fact-based episodic memory and the striatum for procedural learning and memory. Here we directly tested whether these two systems exhibit independent or coordinated activity patterns during procedural learning. We trained rats on a conditional T-maze task requiring navigational and cue-based associative learning. We recorded local field potential (LFP) activity with tetrodes chronically implanted in the caudoputamen and the CA1 field of the dorsal hippocampus during 6-25 days of training. We show that simultaneously recorded striatal and hippocampal theta rhythms are modulated differently as the rats learned to perform the T-maze task but nevertheless become highly coherent during the choice period of the maze runs in rats that successfully learned the task. Moreover, in the rats that acquired the task, the phase of the striatal-hippocampal theta coherence was modified toward a consistent antiphase relationship, and these changes occurred in proportion to the levels of learning achieved. We suggest that rhythmic oscillations, including theta-band activity, could influence not only neural processing in cortico-basal ganglia circuits but also dynamic interactions between basal ganglia-based and hippocampus-based forebrain circuits during the acquisition and performance of learned behaviors. Experience-dependent changes in coordination of oscillatory activity across brain structures thus may parallel the well known plasticity of spike activity that occurs as a function of experience.
Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze task. Publishing Authors By Initials
Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze task. Journal Published:
PUBLICATION TYPE: Research Support, N.I.H., Extr
Journal: Proceedings of the National Academy of Sciences of
VOLUME: 104
Page Numbers: 5644-9
Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.
ISSN: 0027-8424
DAY: 19
MONTH: 03
YEAR: 2007
Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze task. Information
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LANGUAGE: eng
NlmUniqueID: 7505876
Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze task. Keywords Mesh Terms:
KEYWORDS: Theta Rhythm
MESH TERMS: physiology
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Grant and Affiliation Information for Learning-related coordination of striatal and hippocampal theta rhythms during acquisition of a procedural maze task.
AFFILIATION: Department of Psychology, St. Lawrence University, Canton, NY 13617, USA.
Country: United States
AGENCY: United States NIMH
GRANT: MH60379
ACRONYM: MH
MEDLINETA: Proc Natl Acad Sci U S A
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