Learning-induced enduring changes in functional connectivity among prefrontal cortical neurons.

Learning-induced enduring changes in functional connectivity among prefrontal cortical neurons. Research Abstract Details 

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Learning-induced enduring changes in functional connectivity among prefrontal cortical neurons. Abstract Text:

Eun H Baeg,Yun B Kim,Jieun Kim,Jeong-Wook Ghim,Jeansok J Kim,Min W Jung,

Current thinking about how memories are stored in the brain has been profoundly influenced by Donald O. Hebb's cell assembly hypothesis, which posits that (1) learning produces a stable alteration in patterns of connectivity among repeatedly coactivated neurons, and (2) memory retrieval involves reactivation of those altered patterns of connectivity. However, learning-induced changes in connectivity that persist over long periods of time have not been clearly demonstrated. In the present study, two spatial navigation tasks and a long-term ensemble recording technique are used to describe long-lasting modifications in functional connectivity (FC) (defined as changes in synchronous firing) of prefrontal cortical neurons in behaving rats. Animals were initially trained to alternate visiting two spatial locations on a figure-8-shaped maze to obtain a reward (alternating task 1). Afterward, while continuing on task 1, animals were additionally trained to visit only one spatial location on the same maze to obtain a reward (unilateral task 2). Multiple single units were recorded while rats were undergoing acquisition, retention, and performance of both tasks. Our data indicate that correlated firing of prefrontal cortical neurons changed significantly in early phases of training when learning rate was maximal but became progressively smaller in later phases when learning reached asymptote. After animals became proficient, FC remained constant, although neuronal activities varied across two different tasks. The present finding of negatively accelerated changes in FC confirms associative learning theories and provides crucial neurophysiological evidence for Hebb's hypothesis.

Learning-induced enduring changes in functional connectivity among prefrontal cortical neurons. Publishing Authors By Initials

EH Baeg,YB Kim,J Kim,JW Ghim,JJ Kim,MW Jung,

For similar reaction time research abstracts see: reaction time research

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Learning-induced enduring changes in functional connectivity among prefrontal cortical neurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 909-18

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 24

MONTH: Jan

YEAR: 2007

Learning-induced enduring changes in functional connectivity among prefrontal cortical neurons. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

Learning-induced enduring changes in functional connectivity among prefrontal cortical neurons. Keywords Mesh Terms:

KEYWORDS: Reaction Time

MESH TERMS: physiology

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Grant and Affiliation Information for Learning-induced enduring changes in functional connectivity among prefrontal cortical neurons.

AFFILIATION: Neuroscience Laboratory, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 443-721, Korea.

Country: United States

AGENCY: United States NIMH

GRANT: R01MH64457

ACRONYM: MH

MEDLINETA: J Neurosci

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