Lead-related nephrotoxicity: a review of the epidemiologic evidence.

Lead-related nephrotoxicity: a review of the epidemiologic evidence. Research Abstract Details 

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Lead-related nephrotoxicity: a review of the epidemiologic evidence. Abstract Text:

E B Ekong,B G Jaar,V M Weaver,

Chronic kidney disease (CKD) represents a major global public health concern. Efforts to prevent and/or slow progression of CKD are essential. Lead nephropathy, characterized by chronic tubulointerstitial nephritis, is a well-known risk of chronic, high-level lead exposure. However, in recent years, lead exposure has declined sharply, particularly in developed countries. We reviewed epidemiologic research in general, occupational, and patient populations to assess whether lead, at current exposure levels, still contributes to nephrotoxicity. Other pertinent topics, such as risk in children, genetic susceptibility, and co-exposure to cadmium, are also considered. The data reviewed indicate that lead contributes to nephrotoxicity, even at blood lead levels below 5 microg/dl. This is particularly true in susceptible populations, such as those with hypertension (HTN), diabetes, and/or CKD. Low socioeconomic status is a risk factor for both lead exposure and diseases that increase susceptibility. Future public health risk for lead-related nephrotoxicity may be most significant in those rapidly developing countries where risk factors for CKD, including obesity and secondary HTN and diabetes mellitus, are increasing more rapidly than lead exposure is declining. Global efforts to reduce lead exposure remain important. Research is also needed to determine whether specific therapies, such as chelation, are beneficial in susceptible populations.

Lead-related nephrotoxicity: a review of the epidemiologic evidence. Publishing Authors By Initials

EB Ekong,BG Jaar,VM Weaver,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Lead-related nephrotoxicity: a review of the epidemiologic evidence. Journal Published:

PUBLICATION TYPE: Review

Journal: Kidney international

VOLUME: 70

Page Numbers: 2074-84

Journal Abbreviation: Kidney Int.

ISSN: 0085-2538

DAY: 25

MONTH: 10

YEAR: 2006

Lead-related nephrotoxicity: a review of the epidemiologic evidence. Information

Number of References: 117

LANGUAGE: eng

NlmUniqueID: 323470

Lead-related nephrotoxicity: a review of the epidemiologic evidence. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: epidemiology

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Grant and Affiliation Information for Lead-related nephrotoxicity: a review of the epidemiologic evidence.

AFFILIATION: Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: 2 R01 ES007198

ACRONYM: ES

MEDLINETA: Kidney Int

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