Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver.

Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. Research Abstract Details 

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Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. Abstract Text:

M Degawa,K Matsuda,H Arai,Y Hashimoto,

The effects of lead nitrate on the induction of hepatic cytochrome P450IA (CYP1A) isoforms, mainly CYP1A2, by aromatic amines (2-methoxy-4-aminoazobenzene, 2-amino-3-methyl-9H-pyrido [2,3-b]indole and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and aryl hydrocarbons (3-methylcholanthrene, benzo[a]pyrene and beta-naphthoflavone) in male F344 rats were examined at the levels of mRNA, protein and activity of the enzymes. Pretreatment of rats with lead nitrate suppressed the expression of hepatic CYP1A enzyme(s), especially CYP1A2, at both levels of protein and activity of the enzyme(s) by treatment with an aromatic amine or an aryl hydrocarbon. On the other hand, the lead nitrate pretreatment suppressed the induction of CYP1A mRNA(s) by an aromatic amine but not by an aryl hydrocarbon. These findings indicate that lead nitrate suppresses the expression of CYP1A enzymes at both stages of post-translation of mRNAs and transcriptional activation of the genes, and further suggest that the pathway for the transcriptional activation of the CYP1A genes by the aromatic amines is different from that by the aryl hydrocarbons.

Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. Publishing Authors By Initials

M Degawa,K Matsuda,H Arai,Y Hashimoto,

For similar organic chemicals: azo compounds: p-aminoazobenzene research abstracts see: organic chemicals: azo compounds: p-aminoazobenzene research

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Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 120

Page Numbers: 547-51

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Sep

YEAR: 1996

Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. Keywords Mesh Terms:

KEYWORDS: p-Aminoazobenzene

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver. Information

Substance Name: Cytochrome P-450 CYP1A2

Registry Number: EC 1.14.14.1

Grant and Affiliation Information for Lead nitrate inhibits the induction of CYP1A mRNAs by aromatic amines but not by aryl hydrocarbons in the rat liver.

AFFILIATION: Faculty of Pharmaceutical Sciences, Tohoku University, Sendai.

Country: JAPAN

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MEDLINETA: J Biochem

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