[Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice]

[Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice] Research Abstract Details 

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[Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice] Abstract Text:

Wen-di Cai,Bao-Qin Han,Chang-Hong Wang,Wan-Shun Liu,Jin-Xin Chu,

OBJECTIVE: To observe the effects of carboxymethyl chitosan calcium (CCC) on concentration of lead, calcium and zincum, and the liver antioxidative capacity in lead poisoned mice. METHODS: Mice were randomly divided into 7 groups, including normal group, calcium carbonate group, lead-model group, and three experimental groups treated with CCC in three different doses, and the CaNa2EDTA positive control group. The lead poisoned mice model was established by giving water contained with lead acetate. CCC was administrated to mice i.g. once a day. Thirty days later, mice were killed and the concentrations of lead, calcium and zincum in blood, liver, brain and femur were determined by atomic absorption spectrophotometer. Maleicdialdehyde (MDA), total antioxidative capacity (T-AOC), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities in liver were measured by using assay kit. RESULTS: CCC significantly reduced the concentration of lead in blood, brain, liver and femur from about 1.56 microg/g, 13.38 microg/g, 16.15 microg/g, 1011.62 microg/g to about 0.50 microg/g, 5.57microg/g, 5.64 microg/g, 457.86 microg/g, and markedly increased the concentration of calcium in femur in lead poisoned mice. CCC had no significant side-effects on concentration of zincum in lead poisoned mice. The antioxidative profile was favorably changed as manifested by decreasing the level of MDA, increasing the activities of SOD, GSH-Px and T-AOC in livers of the in lead poisoned mice. CONCLUSION: CCC might significantly advance the excretion of lead, increase the concentration of calcium in femur and the antioxidative capacity in lead-loaded mice.

[Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice] Publishing Authors By Initials

WD Cai,BQ Han,CH Wang,WS Liu,JX Chu,

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[Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of

VOLUME: 40

Page Numbers: 415-8

Journal Abbreviation: Zhonghua Yu Fang Yi Xue Za Zhi

ISSN: 0253-9624

DAY: 22

MONTH: Nov

YEAR: 2006

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LANGUAGE: chi

NlmUniqueID: 7904962

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Grant and Affiliation Information for [Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice]

AFFILIATION: College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.

Country: China

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MEDLINETA: Zhonghua Yu Fang Yi Xue Za Zhi

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