Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice.

Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice. Abstract Text:

Saisudha Koka,Stephan M Huber,Krishna M Boini,Camelia Lang,Michael ,Florian Lang,Saisudha Koka,Stephan M Huber,Krishna M Boini,Camelia Lang,Michael ,Florian Lang,Saisudha Koka,Stephan M Huber,Krishna M Boini,Camelia Lang,Michael Föller,Florian Lang,

Malaria, a disease accounting for more than one million deaths per year, is caused by intraerythrocytic growth of Plasmodia. Parasitemia may be blunted by suicidal erythrocyte death or eryptosis, which is characterized by cell shrinkage and phosphatidylserine exposure. Triggers of eryptosis include lead nitrate (Pb(NO3)2). As shown here, Pb(NO3)2 (> or = 10 microM) increased phosphatidylserine exposure of Plasmodium falciparum-infected human erythrocytes, an effect significantly more marked than in noninfected cells. Pb(NO3)2 treatment accelerated the clearance of erythrocytes from circulating blood. Parasitemia in Plasmodium berghei-infected mice was significantly decreased and mouse survival significantly enhanced by 100 microM Pb(NO3)2 (20 ppm) in drinking water. The treatment significantly increased reticulocyte number but did not significantly decrease erythrocyte number in noninfected mice and in infected animals mainly triggered the disappearance of P. berghei harbouring erythrocytes. In conclusion, Pb(NO3)2 accelerates eryptosis and subsequent clearance of infected erythrocytes and thus favourably influences the course of malaria.

Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice. Publishing Authors By Initials

S Koka,SM Huber,KM Boini,C Lang,M ,F Lang,S Koka,SM Huber,KM Boini,C Lang,M ,F Lang,S Koka,SM Huber,KM Boini,C Lang,M Föller,F Lang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 363

Page Numbers: 484-9

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 10

MONTH: 09

YEAR: 2007

Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice.

AFFILIATION: Department of Physiology, University of Tübingen, Gmelinstr. 5, D-72076 Tübingen, Germany.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biochem Biophys Res Commun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Lead decreases parasitemia and enhances survival of Plasmodium berghei-infected mice Related Publications

• A comparison of serratus anterior muscle activation during a wall slide exercise and other traditional exercises.
• Accuracy of noninvasive quantification of brain NAA concentrations using PRESS sequence: verification in a swine model with external standard.
• Adaptive ventricular rate smoothing during atrial fibrillation: a pilot comparison study.
• Angiogenic growth factor levels in maternal and fetal blood: correlation with Doppler ultrasound parameters in pregnancies complicated by pre-eclampsia and intrauterine growth restriction.
• Bioinformatics and its impact on clinical research methods.
• Brain potentials in perception: picture complexity and emotional arousal.
• Cell volume regulatory mechanisms.
• Cognition and self-control: cognitive control of painful sensory input.
• Delayed diagnosis of splenic rupture following minor trauma: Beware of comorbid conditions.
• Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle.
• Interlaced optical force-fluorescence measurements for single molecule biophysics.
• Intoxication level and emotional response.
• Longitudinal in vivo reproducibility of cartilage volume and surface in osteoarthritis of the knee.
• Longitudinal relationship of work hours, mandatory overtime, and on-call to musculoskeletal problems in nurses.
• Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension.
• Novel fast semi-automated software to segment cartilage for knee MR acquisitions.
• Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels.
• Relationship of complex spike synchrony bands and climbing fiber projection determined by reference to aldolase C compartments in crus IIa of the rat cerebellar cortex.
• Restriction fragment length polymorphism in the mitochondrial DNA of cloned cattle.
• Server intervention: what chance in Australia?
• Should emergency physicians use B-type natriuretic peptide testing in patients with unexplained dyspnea?
• Suicidal erythrocyte death in sepsis.
• The CD1d-binding glycolipid alpha-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner.
• The measurement of harmful outcomes following drinking on licensed premises.
• [Evaluation of the follow up results of patients with cervical intraepithelial neoplasia III after surgical treatment]
• [Harmony, improvement and progress]
• [Present and future of basic studies on endometriosis]
• [Present and future of studies on endometriosis (part two)]
• [Study of sexual function in women after surgery for stress urinary incontinence]
• [The chick embryo chorioallantioc membrane as a model for in vivo research on anti-angiogenesis in endometriosis]