Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development.

Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. Research Abstract Details 

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Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. Abstract Text:

Robert F Hevner,

Malformations of cortical development (MCDs) are heterogeneous disorders caused by abnormalities of cell proliferation, apoptosis, cell migration, cortical organization, and axon pathfinding. In severe MCDs, the cerebral cortex can appear completely disorganized, or may be replaced by aberrant laminar patterns, as in "4-layered" types of lissencephaly and polymicrogyria. Little is known about the abnormal layers in MCDs and whether they bear any relation to normal cortical layers or how MCDs affect specific neuron types. Normally, each layer contains a defined mixture of different types of pyramidal and nonpyramidal neurons. The neuron types are distinguished by molecular expression as well as morphologic, neurochemical, and electrophysiologic criteria. Patterns of layer-specific mRNA and protein expression reflect the segregation of different neuron types into different layers (e.g. corticospinal projection neurons in layer V). Numerous layer-specific markers have been described in rodent cortex, and increasing numbers are being documented in human and monkey cortex. Applied to MCDs, layer-specific markers have the potential to reveal new insights on pathogenesis, treatment possibilities, and genotype-phenotype correlations. However, much work remains before layer-specific markers become practical tools in diagnostic neuropathology. Additional markers, more extensive documentation of normal expression, and better antibodies compatible with paraffin-embedded tissues will be necessary.

Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. Publishing Authors By Initials

RF Hevner,

For similar cells: stem cells research abstracts see: cells: stem cells research

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Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of neuropathology and experimental neurolo

VOLUME: 66

Page Numbers: 101-9

Journal Abbreviation: J. Neuropathol. Exp. Neurol.

ISSN: 0022-3069

DAY: 3

MONTH: Feb

YEAR: 2007

Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. Information

Number of References: 75

LANGUAGE: eng

NlmUniqueID: 2985192

Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development. Information

Substance Name: Nerve Tissue Proteins

Registry Number: 0

Grant and Affiliation Information for Layer-specific markers as probes for neuron type identity in human neocortex and malformations of cortical development.

AFFILIATION: Department of Pathology, University of Washington, Seattle, Washington, USA. rhevner@u.washington.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS050248

ACRONYM: NS

MEDLINETA: J Neuropathol Exp Neurol

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