Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid.

Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid. Research Abstract Details 

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Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid. Abstract Text:

Keon-Hee Kim,Dong-Hyun Kim,Hyun-Hee Jang,Mihee Kim,Dae-Hwan Kim,Joon-Sik Kim,Jeong-Il Kim,Ho Zoon Chae,Taeho Ahn,Chul-Ho Yun,Keon-Hee Kim,Dong-Hyun Kim,Hyun-Hee Jang,Mihee Kim,Dae-Hwan Kim,Joon-Sik Kim,Jeong-Il Kim,Ho Zoon Chae,Taeho Ahn,Chul-Ho Yun,

The lateral segregation of anionic phospholipids phosphatidic acid (PA), phosphatidylinositol (PI), and phosphatidylserine (PS) was detected after addition of cytochrome P450 2B1 (CYP2B1). The tendency of lipid clustering was highly dependent on the type of anionic phospholipids examined. PA was the most highly clustered while PI and PS clustered to a lesser degree. Moreover, liposomes containing anionic phospholipids form anionic phospholipid-rich microdomains in the presence of CYP2B1. Anionic phospholipids (mostly notably PA) also increased the ability of CYP2B1 to bind to lipid monolayers. In addition to the ability of CYP2B1 to modulate the physical properties of the membrane, the membrane itself can have reciprocal effects on the activity and conformation of CYP2B1. The catalytic activity of CYP2B1 increased as a function of anionic phospholipid concentration and in the presence of 10 mol% PA, the activity increased by 85%. These results suggest a bi-directional coupling between the CYP2B1 and anionic phospholipids.

Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid. Publishing Authors By Initials

KH Kim,DH Kim,HH Jang,M Kim,DH Kim,JS Kim,JI Kim,HZ Chae,T Ahn,CH Yun,KH Kim,DH Kim,HH Jang,M Kim,DH Kim,JS Kim,JI Kim,HZ Chae,T Ahn,CH Yun,

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Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of biochemistry and biophysics

VOLUME: 468

Page Numbers: 226-33

Journal Abbreviation: Arch. Biochem. Biophys.

ISSN: 1096-0384

DAY: 12

MONTH: 10

YEAR: 2007

Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: bi-directional coupling between CYP2B1 and anionic phospholipid. Information

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LANGUAGE: eng

NlmUniqueID: 372430

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AFFILIATION: School of Biological Sciences and Technology and Hormone Research Center, Chonnam National University, Gwangju 500-757, Republic of Korea.

Country: United States

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MEDLINETA: Arch Biochem Biophys

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