Latent virus influences the generation and maintenance of CD8+ T cell memory.

Latent virus influences the generation and maintenance of CD8+ T cell memory. Research Abstract Details 

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Latent virus influences the generation and maintenance of CD8+ T cell memory. Abstract Text:

Brian S Sheridan,Kamal M Khanna,Gregory M Frank,Robert L Hendricks,

The influence of latent virus on CD8+ T cell memory is poorly understood. HSV type 1 specifically establishes latency in trigeminal ganglia (TG) after corneal infection of mice. In latently infected TG, IL-15 deprivation reduced the following: 1) accumulation of HSV-specific CD8+ effector T cells (HSV-CD8(eff)), 2) accumulation of CD127(+) putative HSV-CD8 memory precursors, and 3) the size and functionality of the memory (HSV-CD8(mem)) population. Although compromised in IL-15(-/-) mice, the HSV-CD8(mem) pool persisted in latently infected tissue, but not in noninfected tissue of the same mice. Anti-IL-2 treatment also dramatically reduced the size of the HSV-CD8(eff) population in the TG, but did not influence the concomitant generation of the CD127+ putative HSV-CD8(mem) precursor population or the size or functionality of the HSV-CD8(mem) pool. Thus, the size of the memory pool appears to be determined by the size of the CD127+ CD8(mem) precursor population and not by the size of the overall CD8(eff) pool. HSV-CD8(mem) showed a higher basal rate of proliferation in latently infected than noninfected tissue, which was associated with a reduced population of CD4+FoxP3+ regulatory T cells. Thus, the generation, maintenance, and function of memory CD8+ T cells is markedly influenced by latent virus.

Latent virus influences the generation and maintenance of CD8+ T cell memory. Publishing Authors By Initials

BS Sheridan,KM Khanna,GM Frank,RL Hendricks,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus latency research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus latency research

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Latent virus influences the generation and maintenance of CD8+ T cell memory. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 177

Page Numbers: 8356-64

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Dec

YEAR: 2006

Latent virus influences the generation and maintenance of CD8+ T cell memory. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Latent virus influences the generation and maintenance of CD8+ T cell memory. Keywords Mesh Terms:

KEYWORDS: Virus Latency

MESH TERMS: immunology

Chemical & Substance for Abstract: Latent virus influences the generation and maintenance of CD8+ T cell memory. Information

Substance Name: Interleukin-7 Receptor alpha Subunit

Registry Number: 0

Grant and Affiliation Information for Latent virus influences the generation and maintenance of CD8+ T cell memory.

AFFILIATION: Graduate Program in Immunology, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Country: United States

AGENCY: United States NIAID

GRANT: T32 AI 060525

ACRONYM: AI

MEDLINETA: J Immunol

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