Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells.

Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. Research Abstract Details 

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Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. Abstract Text:

Rebecca L Bernardos,Linda K Barthel,Jason R Meyers,Pamela A Raymond,

Neuronal progenitors in the mammalian brain derive from radial glia or specialized astrocytes. In developing neural retina, radial glia-like Müller cells are generated late in neurogenesis and are not considered to be neuronal progenitors, but they do proliferate after injury and can express neuronal markers, suggesting a latent neurogenic capacity. To examine the neurogenic capacity of retinal glial cells, we used lineage tracing in transgenic zebrafish with a glial-specific promoter (gfap, for glial fibrillary acid protein) driving green fluorescent protein in differentiated Müller glia. We found that all Müller glia in the zebrafish retina express low levels of the multipotent progenitor marker Pax6 (paired box gene 6), and they proliferate at a low frequency in the intact, uninjured retina. Müller glia-derived progenitors express Crx (cone rod homeobox) and are late retinal progenitors that generate the rod photoreceptor lineage in the postembryonic retina. These Müller glia-derived progenitors also remain competent to produce earlier neuronal lineages, in that they respond to loss of cone photoreceptors by specifically regenerating the missing neurons. We conclude that zebrafish Müller glia function as multipotent retinal stem cells that generate retinal neurons by homeostatic and regenerative developmental mechanisms.

Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. Publishing Authors By Initials

RL Bernardos,LK Barthel,JR Meyers,PA Raymond,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of neuroscience : the official journal

VOLUME: 27

Page Numbers: 7028-40

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 27

MONTH: Jun

YEAR: 2007

Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: metabolism

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Grant and Affiliation Information for Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells.

AFFILIATION: Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109-1048, USA.

Country: United States

AGENCY: United States NEI

GRANT: R01EY004318

ACRONYM: EY

MEDLINETA: J Neurosci

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