Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database.

Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. Research Abstract Details 

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Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. Abstract Text:

K A Soltys,G V Mazariegos,R H Squires,R K Sindhi,R Anand, ,K A Soltys,G V Mazariegos,R H Squires,R K Sindhi,R Anand, ,

Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2% and 89.2%, respectively. Graft loss after the first year was caused by rejection in 49% of the cases with sequelae of technical complications accounting for an additional 20% of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8% of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM.

Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. Publishing Authors By Initials

KA Soltys,GV Mazariegos,RH Squires,RK Sindhi,R Anand, ,KA Soltys,GV Mazariegos,RH Squires,RK Sindhi,R Anand, ,

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Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of transplantation : official jou

VOLUME: 7

Page Numbers: 2165-71

Journal Abbreviation: Am. J. Transplant.

ISSN: 1600-6135

DAY: 3

MONTH: 07

YEAR: 2007

Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database. Information

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LANGUAGE: eng

NlmUniqueID: 100968638

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Grant and Affiliation Information for Late graft loss or death in pediatric liver transplantation: an analysis of the SPLIT database.

AFFILIATION: Hillman Center for Pediatric Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Country: Denmark

AGENCY: United States NIDDK

GRANT: U01-DK061693-01A1

ACRONYM: DK

MEDLINETA: Am J Transplant

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