Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues.

Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues. Research Abstract Details 

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Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues. Abstract Text:

Ricardo Carrion,Kathleen Brasky,Keith Mansfield,Curtis Johnson,Monica Gonzales,Anysha Ticer,Igor Lukashevich,Suzette Tardif,Jean Patterson,

Lassa virus causes thousands of deaths annually in western Africa and is considered a potential biological weapon. In an attempt to develop a small nonhuman primate model of Lassa fever, common marmosets were subcutaneously inoculated with Lassa virus strain Josiah. This inoculation resulted in a systemic disease with clinical and morphological features mirroring those in fatal human Lassa infection: fever, weight loss, high viremia and viral RNA load in tissues, elevated liver enzymes, and severe morbidity between days 15 and 20. The most prominent histopathology findings included multifocal hepatic necrosis with mild inflammation and hepatocyte proliferation, lymphoid depletion, and interstitial nephritis. Cellular aggregates in regions of hepatocellular necrosis were largely composed of HAM56-positive macrophages, devoid of CD3-positive and CD20-positive cells, and characterized by marked reductions in the intensity of HLA-DP, DQ, DR staining. A marked reduction in the major histocompatibility complex class II expression was also observed in the lymph nodes. Immunophenotypic alterations in spleen included reductions in overall numbers of CD20-positive and CD3-positive cells and the disruption of lymphoid follicular architecture. These findings identify the common marmoset as an appropriate model of human Lassa fever and present the first experimental evidence that replication of Lassa virus in tissues is associated with alterations that would be expected to impair adaptive immunity.

Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues. Publishing Authors By Initials

R Carrion,K Brasky,K Mansfield,C Johnson,M Gonzales,A Ticer,I Lukashevich,S Tardif,J Patterson,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 6482-90

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 4

MONTH: 04

YEAR: 2007

Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues. Information

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LANGUAGE: eng

NlmUniqueID: 113724

Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

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Substance Name: Antigens, CD3

Registry Number: 0

Grant and Affiliation Information for Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues.

AFFILIATION: Department of Virology and Immunology, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA.

Country: United States

AGENCY: United States NIAID

GRANT: U54 AI57168

ACRONYM: AI

MEDLINETA: J Virol

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