Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion.

Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion. Research Abstract Details 

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Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion. Abstract Text:

Keiko Nakazato,Chol Kim,Katsuyuki Terajima,Satoru Murata,Hitoshi Fujitani,Kazuhiro Nakanishi,Hiroyuki Tajima,Tatsuo Kumazaki,Atsuhiro Sakamoto,Keiko Nakazato,Chol Kim,Katsuyuki Terajima,Satoru Murata,Hitoshi Fujitani,Kazuhiro Nakanishi,Hiroyuki Tajima,Tatsuo Kumazaki,Atsuhiro Sakamoto,

PURPOSE: Negative-balance isolated pelvic perfusion (NIPP) is used to administer high doses of anticancer drugs such as cisplatin to patients with advanced cancer of the pelvic region. Although the drugs are intended to be specifically delivered to the pelvis, their leakage into the systemic circulation can cause acute renal failure. This study examines the loading volume required for preservation of renal function during anesthesia of NIPP. METHODS: Pelvic cancer patients were assigned to NIPP according to its enrollment criteria. Patients with heart failure, uncontrollable hypertension, renal failure, pulmonary disease or contraindication for the contrast media were excluded. We compared the current anesthesia management regime with a previous protocol, with regard to the loading volume and renal function as assessed by the calculated glomerular filtration rate (GFR). The correlation between the total loading volume and the GFR ratio (GFR after NIPP/GFR before NIPP) was evaluated to define adequate volume loading. RESULTS: The GFR ratios were 0.86 +/- 0.29 and 1.12 +/- 0.25 for the previous and current procedures, respectively. The regression line showed that a minimum loading volume of 28.8 ml kg(-1) h(-1) was required to maintain a GFR ratio of > or =1. CONCLUSIONS: A large volume infusion preserves the GFR despite high-dose cisplatin administration by NIPP.

Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion. Publishing Authors By Initials

K Nakazato,C Kim,K Terajima,S Murata,H Fujitani,K Nakanishi,H Tajima,T Kumazaki,A Sakamoto,K Nakazato,C Kim,K Terajima,S Murata,H Fujitani,K Nakanishi,H Tajima,T Kumazaki,A Sakamoto,

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Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cancer research and clinical oncology

VOLUME: 133

Page Numbers: 741-7

Journal Abbreviation: J. Cancer Res. Clin. Oncol.

ISSN: 0171-5216

DAY: 15

MONTH: 05

YEAR: 2007

Large volume loading to prevent cisplatin-induced nephrotoxicity during negative-balance isolated pelvic perfusion. Information

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LANGUAGE: eng

NlmUniqueID: 7902060

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AFFILIATION: Department of Anesthesiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8602, Tokyo, Japan. k-nakazato@nms.ac.jp

Country: Germany

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MEDLINETA: J Cancer Res Clin Oncol

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