Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading.

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Abstract Text:

Bo Xu,Henry Pelish,Tomas Kirchhausen,Gerald B Hammond,

We describe a large scale synthesis of secramine A. Consistent with its ability to inhibit activation of the small GTPase Cdc42, we find that secramine A inhibits cell spreading, a process previously shown to be Cdc42-dependent.

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Publishing Authors By Initials

B Xu,H Pelish,T Kirchhausen,GB Hammond,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins: cdc42 gtp-binding protein research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins: cdc42 gtp-binding protein research

PUBMED ID PMID:

MEDLINE DATE:

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Organic & biomolecular chemistry

VOLUME: 4

Page Numbers: 4149-57

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 21

MONTH: Nov

YEAR: 2006

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101154995

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Keywords Mesh Terms:

KEYWORDS: cdc42 GTP-Binding Protein

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Information

Substance Name: cdc42 GTP-Binding Protein

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading.

AFFILIATION: Department of Chemistry, University of Louisville, Louisville, Kentucky, 40292, USA.

Country: England

AGENCY: United States NIGMS

GRANT: GM 62566

ACRONYM: GM

MEDLINETA: Org Biomol Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading Related Publications

• A classification of handedness using the Annett Hand Preference Questionnaire.
• Adenylyl cyclase gene transfer in heart failure.
• Adenylylcyclase gene transfer increases function of the failing heart.
• Androstene-3,5-dienes as ER-beta selective SERMs.
• Axial patterning in the developing vertebrate inner ear.
• Cell-based GATA4 cardiac gene transfer using cell-penetrating peptide.
• Combined oral contraceptives: a comprehensive review.
• Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae.
• Editorial--Individuation through socialization.
• Effect of burn injury on corticosteroid-binding globulin levels in plasma and wound fluid.
• Food at end of life.
• Intramolecular hydroamination of difluoropropargyl amides: regioselective synthesis of fluorinated beta- and gamma-lactams.
• Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading.
• Mechanisms responsible for the enhanced antinociceptive effects of micro-opioid receptor agonists in the rostral ventromedial medulla of male rats with persistent inflammatory pain.
• MicroRNAs as tumor suppressors.
• Microarray Analysis of miRNA Gene Expression.
• New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy.
• Ovarian mucinous tumour arising in mature cystic teratoma and associated with pseudomyxoma peritonei: report of two cases and comparison with ovarian involvement by low-grade appendiceal mucinous tumour.
• Promoting the peer-related social development of young children with mild developmental delays: effectiveness of a comprehensive intervention.
• Selective synthesis of fluorinated furan derivatives via AgNO3-catalyzed activation of an electronically deficient triple bond.
• Sex hormone-binding globulin expression in sea bass (Dicentrarchus labrax L.) throughout development and the reproductive season.
• Suitability of the retrograde tracer Dil for electrophysiological studies of brainstem neurons: adverse ramifications for G-protein coupled receptor agonists.
• Testicular, semen and blood parameters in adapted and nonadapted Bos taurus bulls in the semi-arid tropics.
• The Bead blot: a method for selecting small molecule ligands for protein capture and purification.
• The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells.
• The cost-effectiveness of pharmacist-led treatment of cardiac risk in patients with type 2 diabetes.
• The glare hypothesis of macular pigment function.
• Therans-3-enoic acids ofAster alpinus andArctium minus seed oils.
• Three-dimensional face shape in Fabry disease.
• microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder.