Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type.

Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type. Research Abstract Details 

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Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type. Abstract Text:

Lei Wang,Faisal Beg,Tilak Ratnanather,Can Ceritoglu,Laurent Younes,John C Morris,John G Csernansky,Michael I Miller,

In large-deformation diffeomorphic metric mapping (LDDMM), the diffeomorphic matching of images are modeled as evolution in time, or a flow, of an associated smooth velocity vector field v controlling the evolution. The initial momentum parameterizes the whole geodesic and encodes the shape and form of the target image. Thus, methods such as principal component analysis (PCA) of the initial momentum leads to analysis of anatomical shape and form in target images without being restricted to small-deformation assumption in the analysis of linear displacements. We apply this approach to a study of dementia of the Alzheimer type (DAT). The left hippocampus in the DAT group shows significant shape abnormality while the right hippocampus shows similar pattern of abnormality. Further, PCA of the initial momentum leads to correct classification of 12 out of 18 DAT subjects and 22 out of 26 control subjects.

Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type. Publishing Authors By Initials

L Wang,F Beg,T Ratnanather,C Ceritoglu,L Younes,JC Morris,JG Csernansky,MI Miller,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: IEEE transactions on medical imaging

VOLUME: 26

Page Numbers: 462-70

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ISSN: 0278-0062

DAY: 3

MONTH: Apr

YEAR: 2007

Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type. Information

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LANGUAGE: eng

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Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: methods

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Grant and Affiliation Information for Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type.

AFFILIATION: Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S. Euclid Ave, St. Louis, MO 63110, USA. lei@wustl.edu

Country: United States

AGENCY: United States NIMH

GRANT: R01-MH60883

ACRONYM: MH

MEDLINETA: IEEE Trans Med Imaging

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