Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas.

Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas. Research Abstract Details 

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Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas. Abstract Text:

D Ferluga,B Luzar,A Vodovnik,M Poljak,A Cör,N Gale,V Kambic,

Some studies have shown a reduced density of Langerhans cells (LCs) within epithelium infected by human papillomaviruses (HPV) types 16/18. However, data on a correlation between HPV types 6/11 infection and LCs have been missing. To solve this problem, we analysed 24 biopsy specimens of laryngeal papillomas, selected randomly, 20 multiple and 4 solitary. The presence of HPV 6 and 11 was proven by polymerase chain reaction (PCR) using 2 different sets of primers in 23 biopsy specimens. Abnormalities of the covering stratified squamous epithelium were graded according to the Kambic-Gale classification. LCs were immunohistochemically labelled with 2 different antibodies, CD1a and S100. Quantitative analysis was performed to determine the density of LC per mm2 in different grades of epithelial abnormalities covering laryngeal papillomas. Although no statistically significant differences in the mean number of LCs per mm2 of the cross-sectioned epithelium covering laryngeal papillomas were observed comparing simple, abnormal and atypical hyperplasia groups, the mean number of LCs per mm2 in laryngeal papillomas associated with HPV types 6/11 infection substantially exceeded that of the vocal cord surface epithelium in patients with chronic laryngitis.

Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas. Publishing Authors By Initials

D Ferluga,B Luzar,A Vodovnik,M Poljak,A Cör,N Gale,V Kambic,

For similar virus diseases: tumor virus infections research abstracts see: virus diseases: tumor virus infections research

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Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta oto-laryngologica. Supplementum

VOLUME: 527

Page Numbers: 87-91

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: 02

YEAR: 1997

Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas. Keywords Mesh Terms:

KEYWORDS: Tumor Virus Infections

MESH TERMS: pathology

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Grant and Affiliation Information for Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas.

AFFILIATION: Institute of Pathology, Medical Faculty, University of Ljubljana, Slovenia. Ferluga@ibmi.mf.uni-lj.si

Country: NORWAY

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MEDLINETA: Acta Otolaryngol Suppl

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