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Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts.

Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Research Abstract Details 

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  • Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Abstract Text:

    shigetoshi mienoShigetoshi Mieno,hitoshi horimotoHitoshi Horimoto,kenji kishidaKenji Kishida,sachiko horimotoSachiko Horimoto,shinjiro sasakiShinjiro Sasaki,shigetoshi mienoShigetoshi Mieno,hitoshi horimotoHitoshi Horimoto,kenji kishidaKenji Kishida,sachiko horimotoSachiko Horimoto,shinjiro sasakiShinjiro Sasaki,

    The effect of the ultra-short-acting beta blocker, landiolol, on ischemic preconditioning was examined in isolated rabbit hearts. Ischemic preconditioned hearts received 2 episodes of 5 min each of global ischemia and reperfusion. The left anterior descending coronary artery was occluded for 1 hour and reperfused for 1 hour. Left ventricular end-systolic and end-diastolic pressures and infarct size were measured. Seven control hearts had no drug infused. Four groups of 6 hearts each were pretreated with 1 or 3 muM of landiolol or a combination of 1 or 3 muM landiolol and ischemic preconditioning. A further group of 6 hearts had ischemic preconditioning without landiolol. Ischemic preconditioning significantly reduced left ventricular end-diastolic pressure and infarct size compared to the controls. Landiolol alone did not change left ventricular end-diastolic pressure or infarct size, but landiolol 3 muM and ischemic preconditioning decreased left ventricular end-diastolic pressure more than preconditioning alone. These data suggest that pre-ischemic landiolol infusion may enhance the cardioprotective effect of ischemic preconditioning.

    Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Publishing Authors By Initials

    s mienoS Mieno,h horimotoH Horimoto,k kishidaK Kishida,s horimotoS Horimoto,s sasakiS Sasaki,s mienoS Mieno,h horimotoH Horimoto,k kishidaK Kishida,s horimotoS Horimoto,s sasakiS Sasaki,

    For similar abstracts research abstracts see: abstracts research

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    Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: Asian cardiovascular & thoracic annals

    VOLUME: 14

    Page Numbers: 239-43

    Journal Abbreviation:

    ISSN: 1816-5370

    DAY: 22

    MONTH: Jun

    YEAR: 2006

    Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Information

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    LANGUAGE: eng

    NlmUniqueID: 9503417

    Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Keywords Mesh Terms:

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    Grant and Affiliation Information for Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts.

    AFFILIATION: , Department of Thoracic and Cardiovascular Surgery, Osaka Medical College, 2-7 Daigakucho, Takatsuki, Osaka 569-8686, Japan tho050@poh.osaka-med.ac.jp.

    Country: Singapore

    Singapore Research PublicationSingapore Research Publication

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    MEDLINETA: Asian Cardiovasc Thorac Ann

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