Lamivudine treatment-related morphological changes of esophageal varices in patients with liver cirrhosis.

Lamivudine treatment-related morphological changes of esophageal varices in patients with liver cirrhosis. Research Abstract Details 

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Lamivudine treatment-related morphological changes of esophageal varices in patients with liver cirrhosis. Abstract Text:

Hiroyuki Koga,Tatsuya Ide,Kazuhiko Oho,Reiichiro Kuwahara,Teruko Hino,Kei Ogata,Akiko Hisamochi,Kazuo Tanaka,Ryukichi Kumashiro,Atsushi Toyonaga,Michio Sata,

Aim: Many studies have reported the therapeutic effects of lamivudine on cirrhotic patients with hepatitis B; however, no study has investigated the morphological changes of esophageal varices after lamivudine treatment. Method: The morphological changes of esophageal varices in patients with cirrhosis were retrospectively compared between 12 patients treated with lamivudine and six historical untreated patients. Results: In the treated group, the HBV DNA and hyaluronic acid (HA) levels in the serum were significantly lower than those in the untreated group (P = 0.013 and P = 0.009, respectively) at the end of follow-up, with a significant improvement in the Child-Pugh-Turcotte score (P = 0.022). In the treated group, the disappearance or reduction of esophageal varices was observed in six (50%) of the 12 patients. In three (25%) of the 12 patients, esophageal varices worsened. In the remaining three patients (25%), there were no changes in esophageal varices. In the untreated group, all patients showed the worsening of esophageal varices during the follow-up period, with a significant difference between this group and the treated group (P = 0.009). The serum HA level decreased in the nine treated patients without worsening of esophageal varices. However, in the three patients with worsening, the HA level significantly increased. Conclusion: Lamivudine treatment for patients with cirrhosis improves not only liver function but also esophageal varices.

Lamivudine treatment-related morphological changes of esophageal varices in patients with liver cirrhosis. Publishing Authors By Initials

H Koga,T Ide,K Oho,R Kuwahara,T Hino,K Ogata,A Hisamochi,K Tanaka,R Kumashiro,A Toyonaga,M Sata,

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Lamivudine treatment-related morphological changes of esophageal varices in patients with liver cirrhosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 37

Page Numbers: 503-9

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 1

MONTH: Jul

YEAR: 2007

Lamivudine treatment-related morphological changes of esophageal varices in patients with liver cirrhosis. Information

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LANGUAGE: eng

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AFFILIATION: Second Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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