Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain.

Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. Research Abstract Details 

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Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. Abstract Text:

Tae Jung Kim,Luke Freml,Soo Seog Park,Timothy J Brennan,

The substances in wounds that cause incisional pain and hyperalgesia after surgery are poorly understood. We have developed and characterized rat models for incision-induced pain behaviors and measured increased tissue hydrogen ion concentration. Because lactate may facilitate nociceptor responses to low pH and contribute to ischemic pain mechanisms, we measured tissue lactate after incision of the plantar region of the hindpaw, gastrocnemius muscle, and paraspinal region in halothane anesthetized rats using in vivo microdialysis. Incisions were performed at 1 site (plantar, gastrocnemius, or paraspinal incision) in each rat. The corresponding contralateral side was used as the control. In anesthetized rats, a microdialysis fiber was passed into the incision and the control side. L-Lactate was measured using the lactate oxidase method. Tissue concentration was determined from postoperative day 0 to postoperative day 14 using the no net flux method. Lactate was increased on the day of hindpaw incision to 3.6 +/- 1.6 mmol/L compared with control (2.1 +/- .6 mmol/L) and remained increased through 7 days. In the gastrocnemius muscle, lactate was increased the day after incision (4.2 +/- 1.2 mmol/L vs 1.7 +/- .5 mmol/L) until postoperative day 7. On the day of the paraspinal incision, lactate was 3.4 +/- 1.1 mmol/L on the operated side and 2.2 +/- .6 mmol/L in the control side. Lactate remained increased through postoperative day 8 at the paraspinal incision. These experiments demonstrate that incision of the plantar hindpaw, the gastrocnemius muscle, and the paraspinal region increased tissue lactate concentration. The wound environment contains increased lactate at the same time that pH is decreased; lactate could potentially facilitate nociceptor activation by low pH and contribute to pain after surgery. PERSPECTIVE: This study demonstrates that lactate is increased in wounds when pain behaviors and acid are increased. Lactate and low pH are present in incisions and indicate an ischemic pain mechanism that may contribute to postsurgical pain.

Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. Publishing Authors By Initials

TJ Kim,L Freml,SS Park,TJ Brennan,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The journal of pain : official journal of the Amer

VOLUME: 8

Page Numbers: 59-66

Journal Abbreviation:

ISSN: 1526-5900

DAY: 1

MONTH: 09

YEAR: 2006

Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100898657

Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: pathology

Chemical & Substance for Abstract: Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain. Information

Substance Name: Lactic Acid

Registry Number: 50-21-5

Grant and Affiliation Information for Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain.

AFFILIATION: Department of Anesthesia, University of Iowa, Iowa City, IA 52242, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 55831

ACRONYM: GM

MEDLINETA: J Pain

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