Lack of replication of genetic associations with human longevity.

Lack of replication of genetic associations with human longevity. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Lack of replication of genetic associations with human longevity. Abstract Text:

The exceptional longevity of centenarians is due in part to inherited genetic factors, as deduced from data that show that first degree relatives of centenarians live longer and have reduced overall mortality. In recent years, a number of groups have performed genetic association studies on long-living individuals (LLI) and young controls to identify alleles that are either positively or negatively selected in the centenarian population as consequence of a demographic pressure. Many of the reported studies have shown genetic loci associated with longevity. Of these, with the exception of APOE, none have been convincingly reproduced. We validated our populations by typing the APOE locus. In addition, we used 749 American Caucasian LLI, organized in two independent tiers and 355 American Caucasian controls in the attempt to replicate previously published findings. We tested Klotho (KL)-VS variant (rs952706), Cholesteryl Ester Transfer Protein (CETP) I405V (rs5882), Paraoxonase 1 (PON1) Q192R (rs662), Apolipoprotein C-III (APOC3) -641C/A (rs2542052), Microsomal Transfer Protein (MTP) -493G/T (rs2866164) and apolipoprotein E (APOE) epsilon2 and epsilon4 isoforms, (rs7412 and rs429358) haplotypes respectively. Our results show that, at present, except for APOE, none of the selected genes show association with longevity if carefully tested in a large cohort of LLI and their controls, pointing to the need of larger populations for case-control studies in extreme longevity.

Lack of replication of genetic associations with human longevity. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Lack of replication of genetic associations with human longevity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biogerontology

VOLUME: 9

Page Numbers: 85-92

Journal Abbreviation:

ISSN: 1389-5729

DAY: 23

MONTH: 11

YEAR: 2007

Lack of replication of genetic associations with human longevity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100930043

Lack of replication of genetic associations with human longevity. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Lack of replication of genetic associations with human longevity. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Lack of replication of genetic associations with human longevity.

AFFILIATION: Genetic Department, IRCCS Multimedica, via Milanese 300, Sesto S. Giovanni (Milan), 20099, Italy.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biogerontology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Lack of replication of genetic associations with human longevity Related Publications

• Exceptional familial clustering for extreme longevity in humans.
• Interictal lack of habituation of mismatch negativity in migraine.
• Lack of replication of genetic associations with human longevity.
• Nociceptive temporalis inhibitory reflexes evoked by CO2-laser stimulation in tension-type headache.
• Some aspects of the clinico-electroencephalographic examination in a case of infantile subacute sporadic encephalitis.
• Steady-state visual-evoked potentials in headache: diagnostic value in migraine and tension-type headache patients.
• The genetics of exceptional human longevity.
• [Hibernation, prolonged sleep and ganglio-blocking agents in psychiatric treatment.]
• [New trends in psychiatric therapy: hibernation therapy, prolonged sleep and neuroplegic drugs.]
• [Not Available.]
• [Not Available.]