Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo.

Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo. Research Abstract Details 

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Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo. Abstract Text:

Anwarul Haque,Manabu Nishikawa,Wei Qian,Masayuki Mashimo,Masaki Hirose,Shuhei Nishiguchi,Masayasu Inoue,

To elucidate the role of mitochondrial DNA (mtDNA) in determination of growth of hepatocellular carcinoma, we examined wild-type Hepa1-6 cells and their rho(0) cells with depleted mtDNA in vitro and in vivo. Cultured rho(0) cells grew more rapidly than did wild-type cells. Production of reactive oxygen species (ROS) was higher in wild-type cells than in rho(0) cells. Hypoxia inhibited the growth of wild-type cells more markedly than that of rho(0) cells. Resistance to mitochondrial respiratory inhibitor-induced cell death was stronger in rho(0) cells than in wild-type cells. rho(0) cells subcutaneously inoculated in the hind thigh of mice grew more rapidly and formed larger solid tumors. These findings indicate that lack of mtDNA increases growth of hepatocellular carcinoma by decreasing ROS production and increasing resistance to mitochondrial respiratory inhibition.

Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo. Publishing Authors By Initials

A Haque,M Nishikawa,W Qian,M Mashimo,M Hirose,S Nishiguchi,M Inoue,

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Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 36

Page Numbers: 209-16

Journal Abbreviation: Hepatol. Res.

ISSN: 1386-6346

DAY: 21

MONTH: 08

YEAR: 2006

Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo.

AFFILIATION: Department of Biochemistry & Molecular Pathology, Osaka City University Medical School, Osaka 545-8585, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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