Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats.

Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats. Research Abstract Details 

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Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats. Abstract Text:

C K Lii,C W Chen,J Y Liu,Y J Ko,H W Chen,

We investigated the effects of alpha-tocopherol on diethylnitrosamine (DEN) initiation-phenobarbital (PB) promotion of hepatic foci in female Sprague-Dawley rats. Groups of eight rats were initiated with DEN (15 mg/kg) at 24 hours of age. After weaning, they received diets containing 500 ppm PB and various concentrations of alpha-tocopherol, deficient (0 ppm), adequate (100 ppm), and supplemented (5,000 ppm), for 24 weeks. Rats fed alpha-tocopherol-supplemented diets had significantly greater hepatic alpha-tocopherol levels than those fed alpha-tocopherol-deficient or -adequate diets (p < 0.05). Liver lipid peroxidation (measured as thiobarbituric acid-reactive substances) was significantly greater in rats fed alpha-tocopherol-deficient diets than in those fed alpha-tocopherol-adequate or -supplemented diets (p < 0.05). The dietary alpha-tocopherol level had no significant effect on the ratios of reduced glutathione (GSH) to oxidized GSH or reduced GSH to total GSH in the liver or on the plasma prostaglandin E2 concentration or on the activities of hepatic cytosolic and particulate protein kinase C. Rats fed alpha-tocopherol-adequate or -supplemented diets had significantly greater hepatic glutathione S-transferase, GSH reductase, and GSH peroxidase activities than those fed alpha-tocopherol-deficient diets (p < 0.05). The dietary alpha-tocopherol level did not significantly affect the formation of hepatic gamma-glutamyl transpeptidase- and placental glutathione S-transferase-positive foci. These results suggest that alpha-tocopherol does not influence hepatic foci formation and that reactive oxygen species may not be the underlying mechanism of hepatic foci formation in this DEN initiation-PB promotion model of hepatocarcinogenesis.

Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats. Publishing Authors By Initials

CK Lii,CW Chen,JY Liu,YJ Ko,HW Chen,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nutrition and cancer

VOLUME: 34

Page Numbers: 192-8

Journal Abbreviation:

ISSN: 0163-5581

DAY: 19

MONTH: 11

YEAR: 1999

Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905040

Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats. Information

Substance Name: Protein Kinase C

Registry Number: EC 2.7.11.13

Grant and Affiliation Information for Lack of effect of dietary alpha-tocopherol on chemically induced hepatocarcinogenesis in rats.

AFFILIATION: Department of Nutrition, Chung Shan Medical College, Taichung, Taiwan.

Country: UNITED STATES

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MEDLINETA: Nutr Cancer

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